Regulation of plasma soluble receptors of TNF and IL-1 in patients with COVID-19 differs from that observed in sepsis - 06/12/24
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Summary |
Objectives |
IL-1α/β and TNF are closely linked to the pathology of severe COVID-19 and sepsis. The soluble forms of their receptors, functioning as decoy receptors, exhibit inhibitory effects. However, little is known about their regulation in severe bacterial and viral infections, which we aimed to investigate in this study.
Methods |
The circulating soluble receptors of TNF (sTNFR1 and sTNFR2) and IL-1α/β (sIL-1R1, sIL-1R2) were evaluated in the plasma of patients with COVID-19, severe bacterial infections, and sepsis and compared with healthy controls. Additionally, IL1R1, IL1R2, TNFRSF1A, and TNFRSF1B expression was evaluated at the single cell level in PBMCs derived from COVID-19 or sepsis patients.
Results |
Plasma concentrations of sIL-1R1, sTNFR1, and sTNFR2 were significantly higher in COVID-19 patients compared to healthy subjects. Notably, sIL-1R1 levels were particularly elevated in ICU COVID-19 patients, and transcriptome analysis indicated heightened IL1R1 expression in PBMCs from severe COVID-19 patients. In severe bacterial infections, only sTNFR1 and sTNFR2 exhibited increased levels compared to healthy controls. Sepsis patients had decreased sIL-1R1 plasma concentrations but elevated sIL-1R2, sTNFR1, and sTNFR2 levels compared to healthy individuals, reflecting the heightened expression due to the increased numbers of monocytes present in sepsis. Finally, elevated concentrations of sIL-1R2, sTNFR1, and sTNFR2 were moderately associated with reduced 28-day survival in sepsis patients.
Conclusion |
Our study reveals distinct regulation of plasma concentrations of soluble IL-1 receptors in COVID-19 and sepsis. Moreover, soluble TNF receptors 1 and 2 consistently rise in all conditions and show a positive correlation with disease severity in sepsis.
Le texte complet de cet article est disponible en PDF.Highlights |
• | sIL-1R1 plasma concentrations were elevated in COVID-19 patients. |
• | sIL-1R2 but not sIL-1R1 plasma concentrations were elevated in sepsis patients. |
• | Plasma sTNFR1 and sTNFR2 were elevated in both COVID-19 and sepsis patients. |
• | Transcriptional regulation varied across PBMC subpopulations in COVID-19 and sepsis. |
• | sIL-1R2, sTNFR1, and sTNFR2 were associated with increased severity in sepsis. |
Abbreviations : ADAM17, AUC, APACHE-II, ARDS, BMI, CCI, CI, CO-RADS, COVID-19, CRP, CT, CV, DC, DEG, EDTA, ELISA, GCP, ICU, IL-1, IL-1R1, IL-1R2, IL-1RA, IL-1RacP, mDC, MODS, N/A, NK, PBMCs, pDC, ROC, RT-PCR, SARS-CoV-2, SD, SOFA, scRNA-seq, sIL-1R1, sIL-1R2, SIRS, TIR, sTNFR1, sTNFR2, TNF, TNFR1, TNFR2, UMAP
Keywords : COVID-19, Sepsis, STNFR1, STNFR2, SIL-1R1, SIL-1R2
Plan
Vol 89 - N° 6
Article 106300- décembre 2024 Retour au numéro
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