Near real-time severe acute respiratory illness surveillance characterising influenza and COVID-19 epidemiology in hospitalised adults, 2021-22 - 06/12/24
, Neil McInnes b, Andrew Blunsum b, Joanna Quinn b, Daniel Lynagh c, Michael E. Murphy d, e, Rory Gunson f, Alisdair MacConnachie b, David J. Lowe b, g
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Summary |
Objectives |
We report the findings of a novel enhanced syndromic surveillance that characterised influenza- and SARS-CoV-2-associated severe acute respiratory illness (SARI) in the 2021/2022 winter season.
Methods |
Prospective cohort study of adults admitted to the Queen Elizabeth University Hospital, Glasgow, with a severe acute respiratory illness. Patient demographics, clinical history, admission details, and outcomes were recorded. Data were available to Public Health Scotland (PHS) and clinicians weekly.
Results |
Between November 2021 and May 2022, 1063 hospitalised SARI episodes in 1037 adult patients were identified. Median age was 72.0 years, and 44.5% were male. Most (82.6%) SARI cases had ≥1 co-morbidity; chronic lung disease (50.0%) and malignancy (22.5%) were the most frequently reported.
Overall, 229 (22%) and 33 (3%) SARI episodes were SARS-CoV-2 and influenza A PCR positive, respectively. 74.7%, 6.5% and 43.0% SARI episodes received antibiotics, antivirals, and steroids, respectively (54.5%, 11.0% and 51.3% among COVID-19 patients). 1.1% required mechanical ventilation and 7.8% died. Male sex, multimorbidity, frailty, respiratory rate >30, low GCS and chest X-ray consolidation were predictive of in-hospital mortality.
Conclusion |
Near real-time hospitalised SARI syndromic surveillance characterised the evolving clinical epidemiology of SARS-CoV-2 and influenza, high antimicrobial use, and predictors of inpatient mortality among hospitalised SARI patients.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Syndromic adult SARI surveillance provided near real-time data to PHS & clinicians. |
• | SARS-CoV-2 dominant pathogen in 2021/22 season, but influenza activity was low. |
• | 60% required supplemental oxygen, but only ∼1% required mechanical ventilation. |
• | 45% had appropriate microbiological investigations but 75% received antibiotics. |
• | Male, multimorbidity, frailty, RR>30, low GCS & consolidation predicted mortality. |
Keywords : Syndromic surveillance, Severe acute respiratory illness, Influenza, SARS-CoV-2, COVID-19
Plan
Vol 89 - N° 6
Article 106338- décembre 2024 Retour au numéro
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