Clinical profile of herpes zoster-related hospitalizations and complications: A French population-based database study - 06/12/24
, Laetitia Roustand b, ⁎ , Aurélie Schmidt c , Pandora Jacquemet b , Benoît de Wazières d , Clémentine Vabre c , Marie Nishimwe b, e, 1 , Emmanuel Faure f Summary |
Objective |
To estimate the incidence of hospitalization with a diagnosis of herpes zoster (HZ) and post-herpetic neuralgia (PHN) in France between 2013 and 2020, overall and stratified by age-group and immune status.
Methods |
Retrospective observational, database study, using the French hospital discharge database, which includes private and public data for all day-care and inpatient stays. Adults aged ≥18 years, hospitalized between January 1, 2013, and December 31, 2020, with a diagnosis of HZ or PHN, were included.
Results |
Overall, 62 077 adults had a first hospitalization with a diagnosis of HZ or PHN during the observation period. HZ and/or PHN incidence ranged between 14.6 and 16.3 hospitalizations/100 000 persons and was highest in people aged ≥80 years (97.6 hospitalizations/100 000 persons).
The immunocompromised (IC) population accounted for 22% of the overall study population. IC patients had longer lengths of stay for HZ per episode compared with non-IC patients (15.5 ± 19.4 days vs 12.2 ± 13.5 days) and higher in-patient mortality (8% vs 4%).
Average annual hospitalization costs per patient were higher in the IC vs non-IC population (€8018 vs €5603).
Conclusions |
Older age increases hospitalization rates up to 6-fold and IC status increases in-patient mortality up to two-fold.
Clinical Trial Registration |
The study was conducted by HEVA and data were provided by ATIH according to French regulatory and data protection procedures.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Retrospective, medico-economic analysis using the French hospital database. |
• | Between 2013 and 2020, 62 077 adults were hospitalized with herpes zoster or PHN. |
• | 22% of hospitalized people were immunocompromised (IC) and have prolonged stay. |
• | Risk of in-hospital death was higher in the IC vs non-IC population (8% vs 4%). |
• | Mean annual cost per patient was higher in IC vs non-IC population (€8018 vs €5603). |
Keywords : Herpes zoster, Post-herpetic neuralgia, Incidence, Hospitalization
Plan
| Previous congress activities: The data reported in this manuscript were presented at the 15th annual AFCROs DSVR congress. |
Vol 89 - N° 6
Article 106330- décembre 2024 Retour au numéro
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