Inflammatory cytokine responses in pediatric tuberculosis with or without SARS-CoV-2 seropositivity - 06/12/24
, Sarath Balaji c, 1, Poorna Ganga Devi a, Balaji Ramraj a, Arul Nancy b, Nandhini Selvaraj b, Shaik Fayaz Ahamed a, Karthik M a, Suba S a, A. Gunasundari a, A. Seetha a, Poovazhagi Varadarajan c, Elilarasi S c, Aishwarya Venkataraman a, ⁎, 2 , Subash Babu b, d, 2
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Summary |
Objectives |
To characterize the inflammatory cytokine profiles in children with TB in the presence and absence of SARS-CoV2 seropositivity.
Methods |
This study evaluated cytokine responses in two groups of children with TB: CoV2+ (TB and SARS-CoV2 seropositive) and CoV2- (TB and SARS-CoV2 seronegative). Each group had 30 children, and cytokine levels were measured at baseline, months 3 and 6.
Results |
At baseline, CoV2+ children exhibited significantly elevated levels of cytokines, including IFN-γ, IL-2, TNFα, IL-1α, and IL-6, and reduced levels of IL-1β and IL-18, compared to CoV2- children. No significant differences in cytokine levels between the groups were observed at months 3 and 6. Additionally, a general decline in cytokine levels was noted over the course of treatment in both groups. A positive correlation was found between most cytokines and SARS-CoV2 IgG spike protein levels at baseline and at month 3 in the CoV2+ group.
Conclusions |
This study is one of the first studies to characterize the systemic inflammatory responses in SARS-CoV2 seropositive and seronegative children with TB from a TB endemic country. The findings enhance our understanding of the immunopathogenesis of TB and SARS-CoV2 seropositivity in children and may inform future therapeutic strategies
Le texte complet de cet article est disponible en PDF.Highlights |
• | Elevated Inflammatory cytokines responses in pediatric TB with SARS-CoV-2 seropositivity. |
• | These findings deepen our understanding of TB and COVID-19 in children, informing future therapies. |
• | Cytokine levels declined during treatment in TB children, regardless of SARS-CoV-2 seropositivity. |
Keywords : Pediatric TB, SARS-CoV2, COVID-19, Cytokines
Plan
Vol 89 - N° 6
Article 106314- décembre 2024 Retour au numéro
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