Mpox Immune response elicited by MVA-BN vaccine over 12 months of follow-up - 06/12/24
Doi : 10.1016/j.jinf.2024.106309
Giulia Matusali 1
Laboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Roma, Italy
Eleonora Cimini 2
Cellular Immunology and Pharmacology Laboratory, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy
Valentina Mazzotta ⁎ 
Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy
∗Correspondence to: Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Via Portuense 292, 00149 Rome, Italy.Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSVia Portuense 292Rome00149Italy
Francesca Colavita, Fabrizio Maggi
Laboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Roma, Italy
Andrea Antinori
Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy
Highlights |
• | One year after MVA-BN, humoral response was detectable in most smallpox-primed people. |
• | One-third of non-primed individuals maintained low MPXV-neutralizing antibodies. |
• | Both groups showed a robust and persistent MVA-BN-specific T-cell response. |
• | T-cell response could provide protection in people with poor humoral response. |
• | This data might be informative on the strategies for booster after a primary course. |
© 2024
The Author(s). Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 89 - N° 6
Article 106309- décembre 2024 Retour au numéro
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