Dual detection of Neoehrlichia mikurensis and Anaplasma phagocytophilum: How biplex PCR led in France to the diagnosis of neoehrlichiosis in post-tick bite fever - 06/12/24
, Marc Astrie a, Mahsa. Mohseni-Zadeh a, Dominique De Briel b, Benoit Jaulhac c, Pierre Boyer c, dHighlights |
• | Neoehrlichia mikurensis (NM) is responsible for flu-like illness after tick bites. |
• | Present in eastern France, NM is underdiagnosed. |
• | PCR targeting both Anaplasma and NM effectively improves NM diagnosis. |
Abstract |
Objectives |
Neoehrlichia mikurensis (NM) is an emerging intracellular bacterium member of the Anaplasmatacecae family. So far, only four cases have been described in France, all of them retrospectively.
Methods |
This study describes two new cases of NM discovered following implementation of a biplex PCR targeting both Anaplasma and NM.
Results |
Two immunocompetent patients developed a flu-like illness within 14 days after an identified tick bite. Both had negative Anaplasma PCR, but by using this biplex PCR NM, infection was diagnosed in both cases. One patient recovered spontaneously while the second was successfully treated by a seven-day course of doxycycline.
Conclusion |
Present in Eastern France, NM is underdiagnosed. Biplex PCR screening of NM with A.phagocytophilum could effectively address this issue.
Le texte complet de cet article est disponible en PDF.Keywords : Neoehrlichia mikurensis, Anaplasma phagocytophilum, Ixodes ricinus, Tick-borne, Pathogens, PCR
Plan
Vol 54 - N° 8
Article 104995- décembre 2024 Retour au numéro
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