Marijuana may lead to increased platelet activity in trauma patients - 21/11/24
, Joel G. Eastes a , Emily A. Reeson a , Eric W. Lam a , Clay A. Rahaman a , Devin M. O'Toole a , Grace C. Tolan a , Oluwatosin A. Babarinde a , Kristina M. Kupanoff b , Dih-Dih Huang b , Michael D. Jones b , Brian R. Czarkowski b , Jordan A. Weinberg b , James N. Bogert b, ⁎ Abstract |
Introduction |
Delta-9-tetraydrocannabinol (THC) usage is associated with venous thromboembolic events (VTE) in trauma patients. We hypothesized that THC + trauma patients would have less platelet inhibition than THC - patients using thromboelastography with platelet mapping (TEG-PM).
Methods |
Results from initial TEG- PM assays and patient's UDS were reviewed between 2019 and 2023. Mean levels of arachidonic acid (AA) and adenosine diphosphate (ADP) percent inhibition were compared by THC status.
Results |
793 patients had TEG-PM and UDS data. Mean levels of arachidonic acid (AA) percentage inhibition were 32.6 ± 34.2. AA inhibition was lower for THC + vs THC- patients (THC+ 23.9 ± 27.0 vs THC- 34.3 ± 35.3, P < 0.001). There was no association between THC status and ADP inhibition (THC+ 32.5 ± 27.1 vs THC- 30.8 ± 28.4, P = 0.536).
Discussion |
To our knowledge, our data are the first to suggest a clinically measurable increase in platelet reactivity in THC + trauma patients. More work is needed to determine if addition of aspirin to the chemoprophylaxis strategy for THC + patients would mitigate the known association of THC with VTE.
Le texte complet de cet article est disponible en PDF.Highlights |
• | THC use is associated with platelet activation. |
• | THC may induce a prothrombotic state through arachidonic acid pathway. |
• | TEG may be used to identify THC + patients at risk for VTE. |
Keywords : Delta-9-tetraydrocannabinol (THC), Platelet mapping, Venous thromboembolism (VTE), Thromboelastography (TEG), Platelet activation
Plan
Vol 238
Article 115822- décembre 2024 Retour au numéro
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