Effectiveness of a Weight-Loss Intervention in Preventing Frailty and Functional Decline in Community-Dwelling Obese Older People. A Randomized Controlled Trial - 21/11/24
, M. Terradellas 1, I. Lorenzo 1, M. Arús 3, E. Burdoy 4, A. Salietti 4, S. Ramírez 5, E. Palomera 1, M. Papiol 6, E. Pleguezuelos 7
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Abstract |
Background |
Obesity is a risk factor for frailty and muscle weakness, so weight loss in obese older adults may prevent frailty and functional decline.
Objective |
To assess the safety and efficacy of a multimodal weight-loss intervention in improving functional performance and reducing frailty risk in obese older adults.
Design |
Randomized controlled trial with 2 parallel arms. SETTING AND PARTICIPANTS: Community-dwelling obese adults aged 65–75 years with body mass index (BMI) 30–39 kg/m2. INTERVENTION: 6-month multimodal intervention based on diet and a physical activity program. Control group: Usual care.
Main and Secondary Outcome Measures |
Frailty (Fried criteria) rate and functional performance at 6, 12, and 24 months of follow-up, respectively.
Intermediate Outcome Measures |
Weight loss, body composition changes, and metabolic and inflammatory biomarker changes.
Results |
N=305. The study intervention increased gait speed at 12 and 24 months of follow-up, but had no significant effect on frailty prevention. It was effective in reducing weight, BMI, fat mass, interleukin 6, and insulin resistance and improving self-reported quality of life.
Conclusions |
The study intervention was not demonstrated to be effective in preventing frailty in obese people aged 65–75 years at 24 months of follow-up. However, it allowed weight loss and a reduction in inflammatory and insulin resistance markers, which could have a long-term effect on frailty that requires further research.
Le texte complet de cet article est disponible en PDF.Key words : Randomized controlled trial, obese, multimodal intervention, frailty, insulin resistance
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| How to cite this article: M. Serra-Prat, M. Terradellas, I. Lorenzo et al. Effectiveness of a Weight-Loss Intervention in Preventing Frailty and Functional Decline in Community-Dwelling Obese Older People. A Randomized Controlled Trial. J Frailty Aging 2022;11(1)91-99; jfa.2021.38 Institutional Review Board Statement: The study protocol was approved by the local ethics committee (reference number CEIC CSdM 60/16). The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Institutional Ethics Committee of Consorci Sanitari del Maresme (CSdM)(protocol code CEIC CSdM-60/16, 26th October 2016). Informed Consent Statement: Written informed consent was obtained from all subjects involved in the study. Conflicts of Interest: The authors have no conflicts of interest to disclose. |
Vol 11 - N° 1
P. 91-99 - janvier 2022 Retour au numéro
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