Associations of Cardiovascular and Non-Cardiovascular Comorbidities with Dementia Risk in Patients with Diabetes: Results from a Large UK Cohort Study - 21/11/24
Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.
Connectez-vous pour en bénéficier!
Abstract |
Background |
Type 2 diabetes (T2D) is an established risk factor for dementia. However, it remains unclear whether the presence of comorbidities could further increase dementia risk in diabetes patients.
Objectives |
To examine the associations between cardiovascular and non-cardiovascular comorbidities and dementia risk in T2D patients.
Design |
Population-based cohort study.
Setting |
The UK Clinical Practice Research Datalink (CPRD).
Participants |
489,205 T2D patients aged over 50 years in the UK CPRD.
Measurements |
Major cardiovascular and non-cardiovascular comorbidities were extracted as time-varying exposure variables. The outcome event was dementia incidence based on dementia diagnosis or dementia-specific drug prescription.
Results |
During a median of six years follow-up, 33,773 (6.9%) incident dementia cases were observed. Time-varying Cox regressions showed T2D patients with stroke, peripheral vascular disease, atrial fibrillation, heart failure or hypertension were at higher risk of dementia compared to those without such comorbidities (HR [95% CI] = 1.64 [1.59–1.68], 1.37 [1.34–1.41], 1.26 [1.22–1.30], 1.15 [1.11–1.20] or 1.10 [1.03–1.18], respectively). Presence of chronic obstructive pulmonary disease or chronic kidney disease was also associated with increased dementia risk (HR [95% CI] = 1.05 [1.01–1.10] or 1.11 [1.07–1.14]).
Conclusions |
A range of cardiovascular and non-cardiovascular comorbidities were associated with further increases of dementia risk in T2D patients. Prevention and effective management of these comorbidities may play a significant role in maintaining cognitive health in T2D patients.
Le texte complet de cet article est disponible en PDF.Key words : Type 2 diabetes, dementia, comorbidity, cohort
Plan
Vol 9 - N° 1
P. 86-91 - janvier 2022 Retour au numéro
Article précédent
- Association between 9p21–23 Locus and Frailty in a Community-Dwelling Greek Population: Results from the Hellenic Longitudinal Investigation of Ageing and Diet
- N. Mourtzi, A. Hatzimanolis, G. Xiromerisiou, E. Ntanasi, M.K. Georgakis, A. Ramirez, S. Heilmann-Heimbach, B. Grenier-Boley, J.C. Lambert, M. Yannakoulia, M. Kosmidis, E. Dardiotis, G. Hadjigeorgiou, P. Sakka, Nikolaos Scarmeas
- The Ups and Downs of Amyloid in Alzheimer’s
- E. Siemers, P.S. Aisen, M.C. Carrillo
Bienvenue sur EM-consulte, la référence des professionnels de santé.