Prognostic Value of a Laboratory Index of Frailty in Older Patients Hospitalized for COVID-19: The COMEPA Study - 21/11/24
, V. Briganò 1, S. Ciriminna 1, A. Ganci 1, F. Bifara 1, F. Pollicino 1, M.C. Garlisi 1, F. Tantillo 1, S. Amodeo 2, G. Rizzo 3, L. Vernuccio 3, P. Mansueto 1, A. Licata 1, L. Giannitrapani 1, L.J. Dominguez 4, M. Barbagallo 1the COMEPA group
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Abstract |
Background |
Several indexes based on clinical and laboratory tests to identify frailty and to predict mortality have been produced. Only two studies, mixing clinical and laboratory parameters were made about a frailty index made of laboratory tests (FI-Lab) and mortality in older patients hospitalized for COVID-19. The aim of this study was to explore the accuracy and precision of an FI-Lab constructed with some common bio-humoral tests and mortality in a cohort of patients hospitalized for COVID-19.
Methods |
The FI-Lab was constructed using 40 different biohumoral tests during the first four days of hospitalization, with a score from 0 to 1. The association between FI-Lab and mortality was assessed using a multivariate Cox’s regression analysis, reported as hazard ratios (HRs) and 95% confidence intervals (CIs). The accuracy of the FI-Lab was reported as area under the curve (AUC) and the precision with the C-Index.
Results |
376 patients (mean age: 65 years; 53.7% males) were initially included. During the follow-up period, 41 deceased. After adjusting for five different factors, an FI-Lab value >0.54, the median value of our cohort, was associated with a relative risk about five times greater than lower values. Modeling FI-LAB as a continous variable, each increase in 0.01 points was associated with an increased risk in mortality of 8.4% (HR=1.084; 95%CI: 1.039–2.044). The FI-Lab was highly accurate (AUC=0.91; 95%CI: 0.87–0.95) and precise (C-Index=0.81) in predicting death.
Conclusions |
A simple index based on common laboratory tests can be used to predict mortality among older people hospitalized for COVID-19.
Le texte complet de cet article est disponible en PDF.Key words : Frailty index, laboratory, mortality, COVID-19, COMEPA
Plan
| Electronic Supplementary Material Supplementary material is available in the online version of this article at jfa.2024.29. How to cite this article: N. Veronese, V. Briganò, S. Ciriminna, et al. Prognostic Value of a Laboratory Index of Frailty in Older Patients Hospitalized for COVID-19: The COMEPA Study. J Frailty Aging 2024; jfa.2024.29 The COMEPA study includes: Affronti Marco, Amodeo Simona, Barbagallo Mario, Briganò Vincenza Maria, Cacioppo Federica, Capitano Walter M., Carruba Luca, Cavaleri Francesco, Catanese Giuseppina, Citarrella Roberto, Di Bella Giovanna, Di Franco Giuseppina, Di Prazza Agnese, Dominguez Ligia Juliana, Giannitrapani Lydia, Licata Anna, La Carruba Anna, Mansueto Pasquale, Mirarchi Luigi, Morgante Maria Chiara, Parinello Alessandra, Pecoraro Emanuela, Peralta Marco, Piccione Ercole, Polizzotto Carla, Pollicino Francesco, Quartetti Federico, Randazzo Giusi, Rizzo Angelo, Rizzo Giuseppina, Sanfilippo Valeria, Soresi Maurizio, Malerba Valentina, Vernuccio Laura, Veronese Nicola, Zerbo Maddalena. |
Vol 13 - N° 3
P. 213-217 - août 2024 Retour au numéro
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