Lifestyle and Socioeconomic Transition and Health Consequences of Alzheimer’s Disease and Other Dementias in Global, from 1990 to 2019 - 21/11/24
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Abstract |
Background |
Previous studies only focused on changes in the global age-specific incidence and mortality for Alzheimer’s disease and other dementias, failed to distinguish between cohort and period effects, and did not discuss risk factors separately.
Methods |
In this study, Alzheimer’s disease disability-adjusted life years (DALYs) data to estimate the burden by gender, age, locations, and social-demographic status for 21 regions from 1990 to 2019. Additionally, trend analysis was performed using the age-period-cohort (APC) model and Join-point model.
Results |
In most regions, indicators (incidence, mortality, and DALYs) increased steadily with socio-demographic index(SDI) increased. The age effects for Alzheimer’s disease and other dementias showed a significant increase from 40 to 95 years. The cohort effects rate ratios (RRs) had a rapid reduction attributed to smoking, high fasting plasma glucose, and high body mass index (BMI).
Conclusions |
Countries in middle-low and low SDI regions have higher levels of risk factor exposure. As a result, rapid and effective government responses are necessary to control dementia risk factors and reduce the disease burden in these countries.
Le texte complet de cet article est disponible en PDF.Key words : Alzheimer’s disease and other dementias, global burden, risk factors, age-period-cohort analysis, join-point
Plan
Vol 11 - N° 1
P. 88-96 - janvier 2024 Retour au numéro
Article précédent
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