Challenges in the Development of Drugs for Sarcopenia and Frailty - Report from the International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force - 21/11/24
, R. Bernabei 2, B. Vellas 3, R.A. Fielding 4, D. Rooks 5, D. Azzolino 1, J. Mariani 6, A.A. Oliva 7, S. Bhasin 8, Y. Rolland 3ICFSR Task Force members
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Abstract |
Sarcopenia and frailty represent two burdensome conditions, contributing to a broad spectrum of adverse outcomes. The International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force met virtually in September 2021 to discuss the challenges in the development of drugs for sarcopenia and frailty. Lifestyle interventions are the current mainstay of treatment options in the prevention and management of both conditions. However, pharmacological agents are needed for people who do not respond to lifestyle modifications, for those who are unable to adhere, or for whom such interventions are inaccessible/unfeasible. Preliminary results of ongoing trials were presented and discussed. Several pharmacological candidates are currently under clinical evaluation with promising early results, but none have been approved for either frailty or sarcopenia. The COVID-19 pandemic has reshaped how clinical trials are conducted, in particular by enhancing the usefulness of remote technologies and assessments/interventions.
Le texte complet de cet article est disponible en PDF.Key words : Aging, pharmacological interventions, physical performance, clinical trial, sarcopenia, frailty
Plan
| Task force members: Sandrine Andrieu (Toulouse, France); Nuria Barcons (Barcelona, Spain); Ann Beliën (Heusden-Zolder, Belgium); Roberto Calle (New York, USA); Maria Camprubi Robles (Columbus, USA); Tommy Cederholm (Uppsala, Sweden); Bill Chan (Beijing, China); Liang-Kung Chen (Taipei City, Taiwan); de Souto Brreto Philipe (Toulouse, France); Carla Delannoy (Vevey, Switzerland); Waly Dioh (Paris, France); John Groarke (New York, USA); Darren Hwee (South San Francisco, USA); Francesco Landi (Rome, Italy); Valérie Legrand (Nanterre, France); Yvette Luiking (Utrecht, The Netherlands); John Morley (St Louis, USA); Marco Pahor (Gainesville, USA); Caterina Parenti (Verone, Italy); Suzette Pereira (Columbus, USA); Erin Quann (Vevey, Switzerland); Susan Roberts (Boston, USA); Michelle Rossulek (New York, USA); Ricardo Rueda (Columbus, USA); Jorge G. Ruiz (Miami, USA); Lisa Tarasenko (New York, USA); Cendrine Tourette (Paris, France); Rob Van Maanen (Paris, France) |
Vol 11 - N° 2
P. 135-142 - avril 2022 Retour au numéro
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