The Association of Apoe E4 Status with Lower Limb Function and Handgrip Strength in Older Adults - 21/11/24
, P. De Souto Barreto 1, 2, Y. Rolland 1, 2, B. Vellas 1, 2The MAPT/DSA Study Group
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Abstract |
Background/Objectives |
Apolipoprotein (ApoE ε4) status has been associated with various cardiovascular diseases and Alzheimer’s Disease. Some studies have found a possible relationship between the presence of an ApoE ε4 allele and the decrease of motor function in healthy older adults. The objective of this study was to measure the cross-sectional and prospective associations of ApoE ε4 status with lower limb function and handgrip strength in older adults.
Design |
Longitudinal observational study using data from a randomized controlled trial.
Setting |
Community-dwelling older adults.
Participants |
1300 older adults (≥70 years old) with ApoE ε4 status from the Multidomain Alzheimer’s Preventive Trial (MAPT) were followed for three years.
Measurements |
Lower-limb function was measured with the Short Physical Performance Battery (SPPB) and muscle strength was measured with a handgrip strength dynamometer. ApoE ε4 status was assessed with a blood draw. Mixed-effect linear regressions were used to examine cross-sectional as well as prospective associations between ApoE ε4 status and the outcomes.
Results |
No significant cross-sectional or prospective associations were found between ApoE ε4 status, lower-limb function and handgrip strength in our study.
Conclusions |
ApoE ε4 status was not associated with motor function in older adults.
Le texte complet de cet article est disponible en PDF.Key words : Apolipoprotein, lower limb function, handgrip strength
Plan
| Electronic Supplementary Material Supplementary material is available for this article at jfa.2019.7 and is accessible for authorized users. |
Vol 8 - N° 2
P. 62-66 - avril 2019 Retour au numéro
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