Despite technological advancements, maxillary rehabilitation remains a significant challenge in Oral and Maxillofacial Surgery. This paper presents the case of a patient who underwent multiple previous procedures for prosthetic rehabilitation without achieving the desired results. The most recent intervention, which resulted in some sequelae, involved the placement of bilateral zygomatic implants. After unsuccessful attempts to maintain these implants, the decision was made to remove them and place a custom subperiosteal implant, produced via additive manufacturing. The patient has now been successfully rehabilitated with these implants for over a year, with no complaints and a notable improvement in her quality of life. The rehabilitation of severely atrophic maxillae using custom subperiosteal implants has proven to be an excellent alternative, offering predictability, the possibility of virtual planning and simulation, and the ability to rehabilitate extensive bone defects.