Esophageal Atresia with Tracheoesophageal Fistula Is Associated with Consanguinity - 08/11/24
, Ohad Hougui, MD 1, 2, ∗, Matan Zerem 3, Maha Omary 3, Zaki Assi, MD 3, 4, Galina Ling, MD 1, 3, Baruch Yerushalmi, MD 1, 3Abstract |
Objective |
To examine the association between nonsyndromic esophageal atresia with tracheoesophageal fistula (EA-TEF) and consanguinity.
Study design |
A retrospective study comparing the incidence of EA-TEF between a low-consanguineous Jewish population and a high-consanguineous Bedouin population. All patients were treated at Soroka University Medical Center, the only tertiary medical center in southern Israel.
Results |
From 2000 to 2022, 579 130 children were born in southern Israel, and 386 915 (66.8%) were Jewish, and 192 215 were Bedouin Muslims. A total of 96 patients were diagnosed with EA-TEF; 83 of them were nonsyndromic. The incidence of EA-TEF was 1.66 cases per 10 000 live births and was statistically higher among the Bedouin population (3 vs 0.95 cases per 10 000 live births; P < .001). The consanguinity rate among the Bedouin group was higher compared with the Jewish (67.8% vs 0%; P < .001). There were no differences in other risk factors.
Conclusions |
The incidence of EA-TEF is higher among the Bedouin population that lives in the same geographic region and has the same medical access as the Jewish population, proposing consanguinity as a risk factor for EA-TEF.
Le texte complet de cet article est disponible en PDF.Abbreviations : EA, EA-TEF, IVF, SOX2, SUMC, TEF, VACTERL
Plan
Vol 275
Article 114242- décembre 2024 Retour au numéro
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