Mucosal Site Detection of Herpes Simplex Virus in Neonates - 08/11/24
Doi : 10.1016/j.jpeds.2024.114212
Rachel J. Graf, MD 1, 2, Ingrith Viviana Hoyos García, MD 2, 3, Alvaro Dendi, MD 2, 4, Natalie O. White, DO 5, Traci Pifer, BSN 2, 6, Rachelle Harris, BA 2, Douglas Salamon, BS 7, Asuncion Mejias, MD, PhD, MsCS 8, Pablo J. Sánchez, MD 1, 2, 6, ⁎ 
1 The Ohio State University College of Medicine, Columbus, OH
2 Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital, Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Perinatal Research, Ohio Perinatal Research Network, Columbus, OH
3 Department of Pediatrics, Hospital Universitario del Valle, Universidad del Valle, Cali, Colombia
4 Department of Neonatology, Centro Hospitalario Pereira Rossell, Universidad de la República, Montevideo, Uruguay
5 Pediatrix Medical Group of Ohio, Columbus, OH
6 Division of Pediatric Infectious Diseases, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH
7 Department of Laboratory Medicine, Microbiology Laboratory, Nationwide Children's Hospital, Columbus, OH
8 Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN
∗Reprint requests: Pablo J. Sánchez, MD, Nationwide Children's Hospital, The Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OhioNationwide Children's HospitalThe Abigail Wexner Research Institute at Nationwide Children's Hospital700 Children's DriveColumbusOhio
Abstract |
From 2001 to 2023, 17 (14%) of 120 neonates with confirmed herpes simplex virus infection tested positive for herpes simplex virus by polymerase chain reaction (PCR) from only mucosal sites without a clinical mucosal lesion. Whether mucosal PCR positivity reflects early infection that may lead to recognizable disease, transient colonization, or a false-positive PCR result remains a clinical conundrum and warrants further study.
Le texte complet de cet article est disponible en PDF.Keywords : acyclovir, neonatal herpes, neonate, PCR
Abbreviations : CSF, HSV, PCR, SEM
Plan
| Current affiliation: Department of Pediatrics, Case Western Reserve University, University Hospitals, Rainbow Babies & Children's Hospital, Cleveland, OH 44106. |
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| The study was presented in part as a poster presentation at the Pediatric Academic Societies Meeting, Washington, DC on 30th April 2023 (Abstract ID 1401532). |
© 2024
Elsevier Inc. Tous droits réservés.
Vol 275
Article 114212- décembre 2024 Retour au numéro
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