Atrial fibrillation with Heart Failure is a constellation of co-morbid conditions that now constitutes a major cardiovascular epidemic, with HF now the most common complication of AF. Mechanistically, both conditions promote substrate disease in the atrium and ventricle. AF is an independent rixk factor in HF progression and pump failure death. While early studies comparing rhythm control antiarrhythmic drugs and rate control drugs showed no significant benefit in cardiovascular outcomes, AF did promote HF emergence and hospitalizations. Newer rhythm control strategies with present day antiarrhythmic drugs and catheter ablation support benefits in cardiovascular outcomes in AF with HF. Catheter ablation improved HF outcomes in HF with reduced ejection fraction but further and larger studies are needed, especially for AF with HF with preserved ejection fraction.