Sex-Based Differences in Clinical Characteristics of Patients with Acute Myocarditis: A Cohort Study - 24/10/24
Abstract |
Background |
This study investigated sex differences in acute myocarditis patients during index hospitalization.
Methods |
We included 365 patients with acute myocarditis, hospitalized with continuous monitoring at the intensive care unit from 2000-2023 into the Basel Myocarditis Cohort study. We compared sex differences in clinical presentation, the presenting electrocardiogram, prior medical history, inflammatory and cardiac biomarkers, cardiac imaging, arrhythmia occurrence, and short- to midterm outcomes.
Results |
Mean age was 41.3 years, and 26.3% were female. Compared with men, women were older (median 49.7 vs 38.3 years, P < .001) at the time of diagnosis and presented more frequently with dyspnea (41 vs 26%, P = .013) and a higher Killip class (P = .011). In the presenting electrocardiogram, men had a higher occurrence of diffuse ST-elevation (38 vs 9%, P < .001) and PQ-depression (31 vs 20%, P = .042), compared with women. Women had higher N-terminal pro B-type natriuretic peptide levels (1180 vs 387 ng/L, P = .015), lower cardiac troponin T levels (389 vs 726 ng/L, P = .006), and fewer segments with nonischemic late gadolinium enhancement on cardiac magnetic resonance imaging (1 vs 3, P = .005), but similar left ventricular ejection fraction (55 vs 55%, P = .629), compared with men. Overall, hospital stay was longer in women compared with men (7 vs 5 days, P = .018), with a similar length of intensive care unit stay (2.6 vs 2.7 days, P = .922). Women more often developed severe arrhythmia (8.3 vs 2.2%, P = .015) and heart failure during the hospitalization (31.3 vs 16.4%, P = .003).
Conclusion |
Compared with men, women with acute myocarditis were older at the time of diagnosis, presented more often with heart failure, and had an increased frequency of severe arrhythmia.
Le texte complet de cet article est disponible en PDF.Keywords : Arrhythmia, Biomarkers, Heart failure, Inflammation, Myocarditis, Sex characteristics
Plan
| Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. |
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| Conflicts of Interest: JB has no conflict of interest. GB has received speaker honoraria from Inari Medical. SCO has no conflict of interest. PH has no conflict of interest. CM reports receiving research support from the Swiss National Science Foundation, the Swiss Heart Foundation, the University Hospital Basel, the University of Basel; Abbott, Beckman Coulter, Brahms, Idorsia, LSI Medience Corporation, Novartis, Ortho Diagnostics, Quidel, Roche, Siemens, Singulex, Sphingotec, SpinChip, all outside the submitted work, as well as speaker honoraria/consulting honoraria from Amgen, Astra Zeneca, Bayer, Boehringer Ingelheim, BMS, Idorsia, Novartis, Osler, Roche, SpinChip, and Sanofi, all paid to the institution. PB has received research funding from the “University of Basel,” the “Stiftung für Herzschrittmacher und Elektrophysiologie,” the “Freiwillige Akademische Gesellschaft Basel,” the “Swiss Heart Foundation,” and Johnson & Johnson; and reports personal fees from BMS, Boston Scientific, and Abbott, all outside the submitted work. SM has no conflicts of interest. MK reports grants from the Swiss National Science Foundation (Grant numbers 33CS30_148474, 33CS30_177520, 32473B_176178, 32003B_197524), the Swiss Heart Foundation, the Foundation for Cardiovascular Research Basel and the University of Basel, grants from Bayer, grants from Pfizer, grants from Boston Scientific, grants from BMS, grants from Biotronik, and grants and personal fees from Daiichi Sankyo. CS has received speaker honoraria from Biosense Webster, Boston Scientific, Biotronik, Microport, and Medtronic, and research grants from Biosense Webster, and Medtronic. PK reports speaker fees from BMS/Pfizer and grants from the Swiss National Science Foundation, Swiss Heart Foundation, Foundation for Cardiovascular Research Basel, and the Machaon Foundation. |
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| Authorship: JB: Writing - original draft, Data curation; GB: Writing - review & editing, Methodology, Conceptualization; SCO: Data curation; PH: Writing - review & editing, Data curation; CM: Writing - review & editing; PB: Writing - review & editing; SM: Writing - review & editing; MK: Writing - review & editing; CS: Writing - review & editing; PK: Writing - original draft, Supervision, Methodology, Data curation, Conceptualization. |
Vol 137 - N° 11
P. 1104 - novembre 2024 Retour au numéro
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