Diet Quality and Epigenetic Aging in the Women’s Health Initiative - 17/10/24
, Denise K. Houston, PhD, RD 2, Meghan B. Skiba, PhD, MS, MPH, RDN 3, Eric A. Whitsel, MD, MPH 4, James D. Stewart, MA 4, 5, Yun Li, PhD 6, 7, Anthony S. Zannas, PhD 8, Themistocles L. Assimes, MD PhD 9, Steve Horvath, PhD, ScD 10, 11, Parveen Bhatti, PhD 12, 13, Andrea A. Baccarelli, MD, PhD 14, Janet A. Tooze, PhD, MPH 1, ∗, Mara Z. Vitolins, DrPH, MPH 1, ∗Abstract |
Background |
Higher diet quality scores are associated with a lower risk for many chronic diseases and all-cause mortality; however, it is unclear if diet quality is associated with aging biology.
Objective |
This study aimed to examine the association between diet quality and a measure of biological aging known as epigenetic aging.
Design |
A cross-sectional data analysis was used to examine the association between three diet quality scores based on self-reported food frequency questionnaire data and five measures of epigenetic aging based on DNA methylation (DNAm) data from peripheral blood.
Participants/setting |
This study included 4,500 postmenopausal women recruited from multiple sites across the United States (1993-98), aged 50 to 79 years, with food frequency questionnaire and DNAm data available from the Women’s Health Initiative baseline visit.
Main outcome measures |
Five established epigenetic aging measures were generated from HumanMethylation450 Beadchip DNAm data, including AgeAccelHannum, AgeAccelHorvath, AgeAccelPheno, AgeAccelGrim, and DunedinPACE.
Statistical analyses performed |
Linear mixed models were used to test for associations between three diet quality scores (Healthy Eating Index, Dietary Approaches to Stop Hypertension, and alternate Mediterranean diet scores) and epigenetic aging measures, adjusted for age, race and ethnicity, education, tobacco smoking, physical activity, Women’s Health Initiative substudy from which DNAm data were obtained, and DNAm-based estimates of leukocyte proportions.
Results |
Healthy Eating Index, Dietary Approaches to Stop Hypertension, and alternate Mediterranean diet scores were all inversely associated with AgeAccelPheno, AgeAccelGrim, and DunedinPACE (P < 0.05), with the largest effects with DunedinPACE. A one standard deviation increment in diet quality scores was associated with a decrement (β ± SE) in DunedinPACE z score of –0.097 ± 0.014 (P = 9.70 x 10-13) for Healthy Eating Index, –0.107 ± 0.014 (P = 1.53 x 10-14) for Dietary Approaches to Stop Hypertension, and –0.068 ± 0.013 (P = 2.31 x 10-07) for the alternate Mediterranean diet.
Conclusions |
In postmenopausal women, diet quality scores were inversely associated with DNAm-based measures of biological aging, particularly DunedinPACE.
Le texte complet de cet article est disponible en PDF.Keywords : Diet quality, DNA methylation, epigenetic Aging, Women, Aging
Plan
| Supplementary materials: Table 2, Table 3, and Table 4 and Figure 3 are available at www.jandonline.org |
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| STATEMENT OF POTENTIAL CONFLICT OF INTEREST No potential conflict of interest was reported by the authors. |
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| FUNDING/SUPPORT This work was supported by the Wake Forest University Claude D. Pepper Older Americans Independence Center (P30 AG021332). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. |
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| ACKNOWLEDGEMENTS The Women’s Health Initiative (WHI) program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services through contracts 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, and 75N92021D00005. The authors thank the WHI investigators and staff for their dedication, and the study participants for their contributions. A full listing of WHI investigators can be found at: WHI-Investigator-Short-List.pdf |
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| AUTHOR CONTRIBUTIONS Conceived and designed the analysis: L. M. Reynolds, D. K. Houston, E. A. Whitsel, J. A. Tooze, and M. Z. Vitolins; contributed data or analysis tools: E. A. Whitsel, J. D. Stewart, Y. Li, T. L. Assimes, S. Horvath, P. Bhatti, and A. A. Baccarelli; performed the analysis and wrote the manuscript: L. M. Reynolds; contributed to the interpretation of the results: L. M. Reynolds, D. K. Houston, M. Skiba, E. A. Whitsel, Y. Li, A. S. Zannas, T. L. Assimes, P. Bhatti, A. A. Baccarelli, J. A. Tooze, and M. Z. Vitolins. All authors provided feedback and helped shape the research, analysis and manuscript. |
Vol 124 - N° 11
P. 1419 - novembre 2024 Retour au numéro
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