The current traditional medication administration method is characterized by a prevalent "one-size-fits-all" approach poses challenges in tailoring medications to individual pharmacokinetic profiles, limiting its applicability in the pharmaceutical sector. In response to this, three-dimensional (3D) printable medical devices for vaginal drug delivery are gaining popularity, due to advancements in Fused Deposition Modeling (FDM) or additive manufacturing (AM) technology. These devices offer distinct Strengths over conventional medication delivery methods, enabling the customization of drugs and the creation of intricate three-dimensional structures with personalized designs. In an additional point of interest, the development of multi-material printing integrates the beneficial properties of a variety of functional substances, presenting diverse opportunities to enhance the efficacy of vaginal drug delivery. Although there have been substantial advancements in manufacturing processes, challenges such as cost-effectiveness, scalability, and compliance with regulations remain substantial hurdles. This review focuses on the recent progress made in the field of printed using three-dimensional technology for vaginal medication delivery devices, addresses the primary challenges that need to be overcome, and explores the potential of manufacturing techniques in shaping the future of dosage forms and drug administration systems.