Atopic dermatitis (AD) is a complex, chronic disease with multiple negative impacts to patients' health, lives, and overall well-being. The lived experience of AD is multidimensional, heterogeneous, and ever-changing, yet an essential contributor to a holistic understanding of disease burden. Real-world self-monitoring of disease burden by patients has potential as a valuable adjunct to clinical and patient-reported assessments in health care settings. Newer digital tools are available to support these activities, providing opportunity for patients and health care providers to identify aspects of self-monitoring that can best support AD care and management goals, treatment outcomes, and minimize patient burden.