Effect of Metformin on systemic chemokine responses during anti-tuberculosis chemotherapy - 05/09/24
, Chandrasekaran Padmapriyadarsini a, Arul Nancy b, M. Tamizhselvan a, Anant Mohan d, Devarajulu Reddy a, N. Poorana Ganga Devi a, Prabakaran Rathinam c, Bharathi Jeyadeepa a, R.K. Shandil e, Randeep Guleria d, Manjula Singh f, Subash Babu bAbstract |
Background |
Metformin (MET), by boosting immunity, has been suggested as a host-adjunctive therapy to anti-tuberculosis treatment (ATT).
Methods |
We evaluated whether adding MET to the standard ATT can alter the host chemokine response. We investigated the influence of metformin on the plasma levels of a wide panel of chemokines in a group of active tuberculosis patients before treatment, at 2nd month of ATT and at 6-months of ATT as part of our clinical study to examine the effect of metformin on ATT.
Results |
Our results demonstrated that addition of metformin resulted in diminished CC (CCL1 and CCL3) and CXC (CXCL-2 and CXCL-10) chemokines in MET arm as compared to non-MET arm at the 2nd month and 6th month of ATT. In addition to this, MET arm showed significantly diminished chemokines in individuals with high bacterial burden and cavitary disease.
Conclusion |
Our current data suggest that metformin alters chemokines responses that could potentially curb excessive inflammation during ATT.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Metformin changes chemokine responses in TB treatment, possibly reducing overly inflammatory reactions. |
• | Metformin effectively modulates and balances inflammation during active TB disease. |
• | Metformin effectively balances inflammation and host responses to M.tb. |
Keywords : Tuberculosis, Metformin, Chemokine, Anti-TB treatment
Plan
Vol 148
Article 102523- septembre 2024 Retour au numéro
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