The role of SEEG in the presurgical decision-making process in MRI-normal mesial temporal lobe epilepsy - 30/08/24

Doi : 10.1016/j.neurol.2024.06.006

H. Catenoix ^a,^b,⁎ , K. Decaestecker ^c, M. Hermier ^d, M. Chochoi ^e, V. Guinet ^a,^b, A. Montavont ^a,^b, J. Isnard ^a,^b, S. Boulogne ^a,^b, W. Szurhaj ^f, C. Haegelen ^b,^g, N. Reyns ^h, M. Guenot ^b,^g, P. Derambure ^e, J. Jung ^a,^b,^{^{1
These authors contributed equally to this work.}}, S. Rheims ^a,^b,^{^{1
These authors contributed equally to this work.}}
^a Department of Functional Neurology and Epileptology, Hospices Civils de Lyon and Lyon 1 University, Lyon, France
^b Lyon Neuroscience Research Center, Inserm U1028, CNRS UMR5292, Lyon 1 University, Lyon, France
^c Departement of Neurology, General Hospital, Valenciennes, France
^d Department of Neuroradiology, Hospices Civils de Lyon, Lyon, France
^e Department of Clinical Neurophysiology, Lille University Medical Center and EA 1046, University of Lille2, Lille, France
^f Department of Clinical Neurophysiology, Amiens University Medical Center, Amiens, France
^g Department of Functional Neurosurgery, Hospices Civils de Lyon and Lyon 1 University, Lyon, France
^h Department of Neurosurgery and Neurooncology, Lille University Roger Salengro Hospital, Lille, France

^⁎Corresponding author at: Department of Functional Neurology and Epileptology, 59, boulevard Pinel, 69677 Bron Cedex, France.Department of Functional Neurology and Epileptology59, boulevard PinelBron Cedex69677France

Sous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le Friday 30 August 2024
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Highlights

•	Epilepsy surgery should be considered for patients with MRI-normal mTLE.
•	SEEG should be included in the surgical decision-making process.
•	SEEG data show different types of seizure organization.
•	SEEG results cannot be predicted from non-invasive investigations.
•	In the 34% of patients temporal resection sparing the hippocampus can be proposed.

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Abstract

Objectives

In patients with mesial temporal lobe epilepsy (mTLE) and normal MRI, anterior temporal lobectomy sparing the hippocampus might be considered because of the risk of post-operative memory deficit. However, it is unclear whether some patients with normal MRI and non-invasive EEG and semiological pattern highly suggestive of mesial temporal seizures demonstrate a seizure onset network sparing the hippocampus, potentially warranting surgery.

Methods

A retrospective study of 17 patients with mTLE epilepsy and normal MRI who underwent SEEG. Only patients whose non-invasive presurgical data suggested an unilateral mesial temporal epileptogenic zone (EZ), as defined by combination of ictal semiology and ictal EEG during scalp video-EEG, were included. SEEG data were analyzed using both visual and quantitative approaches. Two EZ organization were defined: (i) EZ involved the hippocampus at the onset of the ictal discharge (HIP group): (ii) patients in whom a delay>1sec was observed between the seizure onset and the involvement of the hippocampus (nHIP group). Non-invasive clinical and functional imaging data, as well as post-operative outcomes, were compared across groups.

Results

Eleven patients were included in HIP group and 6 in the nHIP group. In the nHIP group, the maximal epileptogenicity was in the amygdala in five patients and in the entorhinal cortex in one. The hippocampus normalized interictal spiking activity was not different between groups. None of the patients characteristics collected during the non-invasive presurgical workup was associated with the SEEG-based organization of the EZ. Twelve patients underwent a surgical resection, including temporal cortectomy sparing hippocampus in six. Seizure and neuropsychological post-operative outcomes were similar.

Conclusion

In patients with MRI-normal mTLE, SEEG should be included in the surgical decision-making process because seizure organization cannot be predicted from non-invasive investigations. When hippocampus is not included in the EZ, temporal resection sparing the hippocampus can be considered.

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Keywords : Epilepsy, SEEG, Hippocampus, Surgery