A novel intervention of molecular hydrogen on the unbalance of the gut microbiome in opioid addiction: Experimental and human studies - 21/08/24
Abstract |
The gut-brain axis mediates the interaction pathway between microbiota and opioid addiction. In recent years, many studies have shown that molecular hydrogen has therapeutic and preventive effects on various diseases. This study aimed to investigate whether molecular hydrogen could serve as pharmacological intervention agent to reduce risks of reinstatement of opioid seeking and explore the mechanism of gut microbiota base on animal experiments and human studies. Morphine-induced conditioned place preference (CPP) was constructed to establish acquisition, extinction, and reinstatement stage, and the potential impact of H2 on the behaviors related to morphine-induced drug extinction was determined using both free accessible and confined CPP extinction paradigms. The effects of morphine on microbial diversity and composition of microbiota, as well as the subsequent changes after H2 intervention, were assessed using 16 S rRNA gene sequencing. Short-Chain Fatty Acids (SCFAs) in mice serum were detected by gas chromatography-mass spectrometry (GC-MS). Meanwhile, we also conducted molecular hydrogen intervention and gut microbiota testing in opioid-addicted individuals. Our results revealed that molecular hydrogen could enhance the extinction of morphine-related behavior, reducing morphine reinstatement. Gut microbes may be a potential mechanism behind the therapeutic effects of molecular hydrogen on morphine addiction. Additionally, molecular hydrogen improved symptoms of depression and anxiety, as well as gut microbial features, in individuals with opioid addiction. This study supports molecular hydrogen as a novel and effective intervention for morphine-induced addiction and reveals the mechanism of gut microbiota.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Molecular hydrogen as a novel intervention to reduce risks of reinstatement of opioid seeking through unbalance the gut microbiome based on animal experiments and human studies.
Molecular hydrogen as a novel intervention to reduce risks of reinstatement of opioid seeking through unbalance the gut microbiome based on animal experiments and human studies.Le texte complet de cet article est disponible en PDF.
Highlights |
• | Molecular hydrogen facilitates the extinction of morphine CPP in mice. |
• | Molecular hydrogen improves anxiety and depression symptoms of opioid addicts. |
• | Opioids alter gut microbial diversity and composition in mice and human. |
• | Gut microbiota play a role in the intervention of molecular hydrogen. |
• | Molecular hydrogen could be a novel intervention for addiction caused by opioid. |
Abbreviations : CCH, CPP, HRW, OTUs, PCoA, SAS, SDS, VAS
Keywords : Opioid, Morphine, Molecular hydrogen, Gut microbiome, Intervention
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Vol 178
Article 117273- septembre 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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