Relevance of harmful intratumoral microbiota in cancer progression and its clinical application - 21/08/24
Abstract |
Microorganisms are closely related to human health, and changes in the microbiome can lead to the occurrence of diseases. With advances in sequencing technology and research, it has been discovered that intratumoral microbiota exists in various cancer tissues and differs in various cancers. Microorganism can colonize tumor tissues through intestine of damaged mucosal barrier, proximity to normal tissues and bloodstream circulation. Increasing evidence suggests that intratumoral microbiota promotes tumor progression by increasing genomic instability, affecting host immune systems, promoting tumor migration, and regulating tumor signaling pathways. This review article summarizes the latest progress in intratumoral microbiome research, including the development history of intratumoral microbiota, their composition and sources within tumors, their distribution in various cancer tissues, as well as their role in cancer development. Furthermore, the application of intratumoral microbiota in clinical settings is emphasized and we innovatively summarize the clinical trials involving microbial applications for cancer diagnosis and treatment across different countries.
Le texte complet de cet article est disponible en PDF.Keywords : Cancer, Intratumor microbiota, Microbiome heterogeneity, Omics technology, Source of microbiota, Tumorigenesis
Plan
Vol 178
Article 117238- septembre 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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