Phosphatidylserine improves aging sepsis survival, modulates gut microbiome, and prevents sepsis-associated encephalopathy - 21/08/24
Abstract |
Aged adults are prone to both short- and long-term complications following sepsis due to ineffective therapy. Phosphatidylserine (PS) is a membrane nutrient supplement known to enhance cognition and brain function, but its potential effects in treating sepsis are not well-documented. Our study aimed to explore the potential of PS in improving outcomes in sepsis and sepsis-associated encephalopathy (SAE). Middle-aged mice were administered PS for two months following induction of sepsis by lipopolysaccharides. The results indicated a significant increase in the survival rate of mice treated with PS after sepsis. Surviving mice underwent open field and shuttle box tests 45 days post-sepsis, revealing potential alleviation of neurobehavioral impairments due to PS pretreatment. Analysis at 60 days post-sepsis euthanasia showed reduced cleaved-caspase 3 in neurons and glial cell markers in the PS-treated group compared to the untreated sepsis group. Furthermore, PS administration effectively reduced proinflammatory cytokine gene expression in the hippocampus of mice with SAE, potentially inhibiting the TBK1/NLRP3/ASC signaling pathway. In the gut, PS pretreatment modulated β-diversity while maintaining jejunal morphology and colon ZO-1 expression, without significantly affecting α-diversity indices. Our findings suggest that PS administration improves survival rates, modulates the gut microbiome, preserves gut integrity, and ameliorates brain pathology in survived mice after sepsis. Importantly, these findings have significant implications for sepsis treatment and cognitive function preservation in aging individuals, providing new insights and sparking further interest and investigation into the potential of PS in sepsis treatment.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Phosphatidylserine increases aging sepsis survival. |
• | Phosphatidylserine improves aging sepsis-associated encephalopathy. |
• | Phosphatidylserine modulates the gut microbiome and maintains gut integrity. |
• | Phosphatidylserine mitigates neuroinflammation and protects from neuron death. |
• | Phosphatidylserine suppresses the TBK1/NLRP3/ASC pathway in the aging hippocampus with SAE. |
Keywords : Phosphatidylserine, Sepsis-associated encephalopathy, Neuroinflammation, Gut integrity, Gut microbiota
Plan
Vol 178
Article 117200- septembre 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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