Characterization of peripheral artery disease and associations with traditional risk factors, mobility, and biomarkers in the project baseline health study - 16/08/24

Doi : 10.1016/j.ahj.2024.06.010

Jacquelyn B. Kercheval, MD ^a, Dennis I. Narcisse, MD, MS ^a, Maggie Nguyen, PhD ^b, Sunil V. Rao, MD ^c, J. Antonio Gutierrez, MD, MHS ^a,^d,^e, Nicholas J. Leeper, MD ^f,^g, David J. Maron, MD ^g,^h, Fatima Rodriguez, MD, MPH ^g, Adrian F. Hernandez, MD, MHS ^e, Kenneth W. Mahaffey, MD ^g,ⁱ, Svati H. Shah, MD, MHS ^a,^b,^e, Rajesh V. Swaminathan, MD ^a,^d,^e,^⁎
on behalf of the
Project Baseline Health Study Group^a
^a Department of Medicine, Duke University School of Medicine, Durham, NC
^b Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC
^c Department of Medicine, NYU Grossman School of Medicine, New York, NY
^d Durham VA Medical Center, Durham, NC
^e Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC
^f Department of Surgery, Stanford University, Stanford, CA
^g Division of Cardiovascular Medicine and the Cardiovascular Institute, Stanford University, Stanford, CA
^h Stanford Prevention Research Center, Stanford University, Stanford, CA
ⁱ Stanford Center for Clinical Research, Stanford University, Stanford, CA

^⁎Reprint requests: Rajesh V. Swaminathan, MD, Department of Medicine, Duke University School of Medicine, 508 Fulton Street (A3014), Durham, NC, 27705Department of MedicineDuke University School of Medicine508 Fulton Street (A3014)DurhamNC27705

Guest Editor: Toru Suzuki

ABSTRACT

Background

There is a dearth of research on immunophenotyping in peripheral artery disease (PAD). This study aimed to describe the baseline characteristics, immunophenotypic profile, and quality of life (QoL) of participants with PAD in the Project Baseline Health Study (PBHS).

Methods

The PBHS study is a prospective, multicenter, longitudinal cohort study that collected clinical, molecular, and biometric data from participants recruited between 2017 and 2018. In this analysis, baseline demographic, clinical, mobility, QoL, and flow cytometry data were stratified by the presence of PAD (ankle brachial index [ABI] ≤0.90).

Results

Of 2,209 participants, 58 (2.6%) had lower-extremity PAD, and only 2 (3.4%) had pre-existing PAD diagnosed prior to enrollment. Comorbid smoking (29.3% vs 14%, P < .001), hypertension (54% vs 30%, P < .001), diabetes (25% vs 14%, P = .031), and at least moderate coronary calcifications (Agatston score >100: 32% vs 17%, P = .01) were significantly higher in participants with PAD than in those with normal ABIs, as were high-sensitivity C-reactive protein levels (5.86 vs 2.83, P < .001). After adjusting for demographic and risk factors, participants with PAD had significantly fewer circulating CD56-high natural killer cells, IgM+ memory B cells, and CD10/CD27 double-positive B cells (P < .05 for all).

Conclusions

This study reinforces existing evidence that a large proportion of PAD without claudication may be underdiagnosed, particularly in female and Black or African American participants. We describe a novel immunophenotypic profile of participants with PAD that could represent a potential future screening or diagnostic tool to facilitate earlier diagnosis of PAD.

ClinicalTrials.gov Identifier

NCT03154346, NCT03154346

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Plan

Background

Methods

PBHS overview

PAD in PBHS participants

Mobility analysis

Quality of life analysis

Immunophenotyping analysis

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Vol 275

P. 183-190 - septembre 2024 Retour au numéro

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Characterization of peripheral artery disease and associations with traditional risk factors, mobility, and biomarkers in the project baseline health study - 16/08/24

ABSTRACT

Background

Methods

Results

Conclusions

ClinicalTrials.gov Identifier

Plan

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