Influenza vaccination and COVID-19 infection risk and disease severity: A systematic review and multilevel meta-analysis of prospective studies - 15/08/24
, Saverio Caini, MD PhD c, Guglielmo Bonaccorsi, MD a, Chiara Lorini, PhD a, John Paget, PhD c, †, Koos van der Velden, MD PhD b, Claudia Cosma, MD d
Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.
Connectez-vous pour en bénéficier!
Résumé |
Background |
In light of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic, the influence of influenza vaccination on the risk and severity of Coronavirus Disease 19 (COVID-19) has been a subject of debate. This systematic review and meta-analysis of prospective studies aim to assess the association between influenza immunization and the risk of SARS-CoV-2 infection and subsequent COVID-19 disease severity.
Methods |
A comprehensive search of PubMed and Embase databases was performed to identify prospective studies published before March 2024. We focused on evaluating the effect of influenza vaccination on SARS-CoV-2 infection risk and severe COVID-19 outcomes, such as hospitalization and mortality. The analysis employed a multilevel random effects meta-analysis approach. The risk of bias assessment was conducted using the Newcastle-Ottawa Scale.
Results |
From an initial pool of 5,863 records, 14 studies were selected for inclusion. The aggregated data yielded a summary relative risk (SRR) that showed no significant protective correlation between influenza vaccination and SARS-CoV-2 infection risk (SRR 0.95, 95% confidence interval [CI] 0.81-1.11), COVID-19-associated hospitalization (SRR 0.90, 95% CI 0.68-1.19), or COVID-19-related mortality (SRR 0.83, 95% CI 0.56-1.23).
Conclusions |
This systematic review and meta-analysis, based exclusively on prospective studies, demonstrates the lack of a proven protective effect of influenza vaccination against COVID-19 and related outcomes. Our results do not support a significant protective effect of influenza vaccination against the risk or severe outcomes of COVID-19.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Influenza vaccination was not associated with a lower SARS-CoV-2 infection risk. |
• | No significant association between influenza vaccination and COVID-19 hospitalization. |
• | Influenza vaccination showed no reduction in COVID-19 associated risk of death. |
Key Words : Human influenza, SARS-CoV-2, Vaccination policies, Public health, Vaccine effectiveness
Plan
| Ethics approval: Ethical approval was not required for this study. |
|
| Conflicts of interest: None to report. |
Vol 52 - N° 9
P. 1091-1098 - septembre 2024 Retour au numéro
Article précédent
- Rapid management of Serratia marcescens outbreak in neonatology unit in Singapore: Risk factors and infection control measures
- Shalvi Arora, Aung Myat Oo, Bushra Shaik Ismail, Woei Bing Poon, Deborah Lai, Karrie Kwan Ki Ko, Hei Man Wong, Kwee Yuen Tan, May Kyawt Aung, Edwin Conceicao, Yong Yang, Darius Yak Weng Chan, Jean Xiang Ying Sim, Indumathi Venkatachalam, Lai Chee Lee, Moi Lin Ling
- Pseudo-outbreak of Parengyodontium album related to contaminated saline used in specimen processing in the microbiology laboratory
- Nancy L. Havill, Nicole A. Colandrea, Jacob Merwede, Michael J. Aniskiewicz, Scott C. Roberts, Kavin Patel, Richard A. Martinello, David R. Peaper
Bienvenue sur EM-consulte, la référence des professionnels de santé.