Cardiovascular disease risk after a SARS-CoV-2 infection: A systematic review and meta-analysis - 10/08/24
, Pauline Kaboth a, 1, Natalie Rath a, David Reissig a, Daniel Kaempf a, Albert Nienhaus b, c, Andreas Seidler a, 3
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Summary |
Objectives |
To our knowledge, there is no systematic review examining CVD risks after a SARS-CoV-2 infection over time, while also taking into account disease severity. All evidence on the risk for pulmonary embolism (PE), myocardial infarction (MI), ischaemic stroke (IS), haemorrhagic stroke (HS), and arterial thrombosis following infection was evaluated.
Methods |
The protocol was registered with PROSPERO. We searched Pubmed, Embase, MedRxiv and screened the titles/abstracts and full texts. We extracted the included studies, assessed their quality, and estimated pooled risks by time after infection and according to disease severity.
Results |
Risks were highest in the acute phase [PE: 27.1 (17.8–41.10); MI: 4.4 (1.6–12.4); stroke: 3.3 (2.1–5.2); IS: 5.6 (2.1–14.8); HS: 4.0 (0.1–326.2)] compared to the post-acute phase [PE: 2.9 (2.6–3.3); MI: 1.4 (1.1–1.9); stroke: 1.4 (1.0–2.0); IS: 1.6 (0.9–2.7)]. Highest risks were observed after infection confirmation, dropping during the first month post-infection (e.g. PE: RR(7 days) = 31; RR(1 month) = 8.1). A doubled risk was still observed until 4.5 months for PE, one month for MI and two months for IS. Risks decreased with decreasing disease severity.
Conclusions |
Because of increased risk of CVD outcomes, management of persons who survived a severe SARS-CoV-2 infection is required, especially during the first nine months post-infection.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Risks highest immediately after infection, but decrease sharply during first month. |
• | Elevated risks long after infection (3 to at least 9 months, depending on outcome). |
• | Hospitalised persons at higher risk for CVD compared to non-hospitalised persons. |
Abbreviations : IS, HS, MI, PE, BTI
Keywords : COVID-19, Arterial thrombosis, Myocardial infarction, Pulmonary embolism, Ischaemic stroke, Haemorrhagic stroke
Plan
Vol 89 - N° 3
Article 106215- septembre 2024 Retour au numéro
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