The functions of cuproptosis in gastric cancer: therapy, diagnosis, prognosis - 23/07/24

Doi : 10.1016/j.biopha.2024.117100

Zhiqin Zhang ^a,^{^{1
These authors have contributed equally to this work}}, Shenhua Shao ^b,^{^{1
These authors have contributed equally to this work}}, Hao Luo ^c,^{^{1
These authors have contributed equally to this work}}, Wangwei Sun ^d, Jianjun Wang ^d,^⁎ , Hongqin Yin ^e,^⁎
^a Department of BioBank, Kunshan Hospital Affiliated to Jiangsu University, Suzhou 215300, PR China
^b Department of Clinical Laboratory, Jinxi People's Hospital of Kunshan, Suzhou, Jiangsu 215300, PR China
^c Department of Clinical Laboratory, the Second People’s Hospital of Kunshan, Suzhou 215300, PR China
^d Department of Clinical Laboratory, Kunshan Hospital Affiliated to Jiangsu University, Jiangsu 215300, PR China
^e Department of Ultrasound, Kunshan Hospital Affiliated to Jiangsu University, Jiangsu 215300, PR China

^⁎Corresponding authors.

Abstract

Gastric cancer (GC) is the fifth most prevalent type of cancer in the whole world. Cuproptosis is discovered as a programmed cell death pathway and connected to cells' growth and death, as well as tumorigenesis. The relationship between cuproptosis and GC is still elusive. Two aspects of this study will elaborate the relationship between cuproptosis and immunotherapy as well as biomarkers in GC. Notably, the herein review is intended to highlight what has been accomplished regarding the cuproptosis for the diagnosis, immunotherapy, and prognosis in GC. The aim of this study is to offer a potential directions and the strategies for future research regarding cuproptosis inside the GC.

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Keywords : Gastric cancer, Cuproptosis, Immunotherapy, Biomarkers, Prognosis

Plan

Introduction

Systemic copper metabolism

The function and mechanism of cuproptosis

The function of copper dysregulation in GC

The functions of cuproptosis in antitumor therapy in GC

The roles of cuproptosis-related genes for biomarkers and prognosis in GC

The roles of cuproptosis-related lncRNAs for biomarkers and prognosis in GC

Future perspective

Funding

CRediT authorship contribution statement

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Vol 177

Article 117100- août 2024 Retour au numéro

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The functions of cuproptosis in gastric cancer: therapy, diagnosis, prognosis - 23/07/24

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