Personalized autologous stem cell harvesting improves patient collection outcomes - 20/07/24
Highlights |
• | Tailoring the apheresis procedures to the patient-specific characteristics and objectives, using harvesting prediction models can improve patients outcomes. |
• | Large-volume leukapheresis can be performed safely if the appropriate care is provided. |
Abstract |
Objectives |
This study aims to demonstrate that utilizing a personalized approach to apheresis stem cell collection, can safely optimize the collection outcomes, especially in the context of poor mobilizers and high cell targets.
Background |
The optimal mobilization and harvesting of peripheral blood stem cells is critical to the success of the stem cell transplant. The ideal strategy that promotes better cell yields, with sustainable use of resources and assuring patient safety, should be pursued.
Methods |
PBSC collections for autologous stem cell transplant data according to a fixed-processed volume strategy (One Size Fits All) or individualized to patients CD34+ peripheral blood content and target approach (Custom-Tailored or CT) were retrospectively compared.
Results |
A total of 263 collections from 142 patients were assessed. The majority of patients were male, had multiple myeloma and were mobilized with isolated G-CSF. The CT strategy promoted a significantly higher CD34+ cell yield when the pre-collection CD34 was lower than 20/µl (1.02 ± 0.16 versus 1.36 ± 0.23, p < 0.001) and also a decrease in the proportion of mobilization cycles that needed 3 apheresis (31% versus 14%, p = 0.02). There was no difference in apheresis-related adverse events between the groups.
Conclusion |
Tailoring the apheresis procedures to the patient-specific characteristics and objectives, can effectively promote better patient outcome.
Le texte complet de cet article est disponible en PDF.Keywords : Apheresis, CD34, Myeloma, Stem cell harvesting, Transplant
Plan
Vol 31 - N° 3
P. 157-161 - août 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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