Hypervirulent Klebsiella pneumoniae-related bacteremia in intensive care unit: A retrospective cohort study - 18/07/24
, Nabil Gastli fHighlights |
• | Hypervirulent KP (hvKP) infections can lead to severe infections and occur primarily in southeast Asia. |
• | Data on hvKP bacteremia in ICUs in high-income countries are scarce. |
• | Socio-demographic and clinical features of patients with hVKP BSI in ICUs differs from classical KP (cKP). |
• | hvKP-BSI has been associated with community-acquired pneumonia in homeless patients. |
• | Further studies are needed to assess hvKP infections in Europe. |
Abstract |
Introduction |
Hypervirulent Klebsiella pneumoniae (hvKP) bloodstream infections (BSI) have rarely been reported in critically ill patients.
Methods |
We conducted a retrospective study of KP-BSI between January 2016 and December 2020 in an adult medical intensive care unit (ICU) of our tertiary care hospital. Hypervirulent phenotype was defined by the detection of both rmpA and iutA.
Results |
Seventy patients diagnosed with K. pneumonia BSI were included, of whom 9 (13 %) had hvKP infection. Pneumonia accounted for 56 % of hvKP-BSI and for 28 % of those with cKP. Fifty-six percent of patients with hvKP-BSI were homeless, versus 2 % of those with cKP-BSI (p < 0.001). The 30-day mortality rate reached 44 % for hvKP-BSI and 34 % for cKP-BSI (p = 0.7) and did not appear related to the hypervirulent phenotype in multivariable analysis.
Discussion |
We here evidenced a new clinical entity of hvKP-BSI associated with pulmonary infection in homeless patients, which exhibits high mortality.
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Vol 54 - N° 5
Article 104892- août 2024 Retour au numéro
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