Long-Term Health-Related Quality of Life in Working-Age COVID-19 Survivors: A Cross-Sectional Study - 17/07/24
, James Wilton, MPH e, Karen C. Tran, MD, MHSc a, b, d, Naveed Zafar Janjua, MBBS, DrPH d, e, f, Adeera Levin, MD a, b, d, Wei Zhang, PhD c, d
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Abstract |
Background |
Most working-age (18-64) adults have been infected with SARS-CoV-2, and some may have developed post-COVID-19 condition (PCC). However, long-term health-related quality of life (HRQOL) following infection remains uncharacterized.
Methods |
In this cross-sectional study, COVID-19 survivors from throughout British Columbia (BC), Canada, completed a questionnaire >2 years after infection. PCC status was self-reported, and HRQOL was assessed using the EuroQol 5-dimension 5-level (EQ-5D-5L) instrument. We compared HRQOL in those with current PCC, those with recovered PCC, and those without a history of PCC. Multivariable analyses were weighted to be representative of COVID-19 survivors in BC.
Results |
Of the 1,135 analyzed participants, 19.2% had current PCC, and 27.6% had recovered PCC. Compared to those without a history of PCC, participants with recovered PCC had a similar mean EQ-5D health utility (adjusted difference -0.02 [95%CI -0.03, 0.00]), but those with current PCC had a lower health utility (adjusted difference -0.08 [95%CI -0.12, -0.05]). Participants with current PCC were also more likely to report problems with mobility (adjusted odds ratio (aOR) 6.00 [95%CI 2.88-12.52]), self-care (aOR 5.96 [95%CI 1.84-19.32]), usual activities (aOR 8.00 [95%CI 4.27-14.99]), pain/discomfort (aOR 4.28 [95%CI 2.46-7.48]), and anxiety/depression (aOR 3.45 [95%CI 1.90-6.27]).
Conclusions |
In working-age adults who have survived >2 years following COVID-19, HRQOL is high among those who never had PCC or have recovered from PCC. However, individuals with ongoing symptoms have lower HRQOL and are more likely to have functional deficits. These findings underscore the importance of implementing targeted healthcare interventions to improve HRQOL in adults with long-term PCC.
Le texte complet de cet article est disponible en PDF.Keywords : Activities of daily living, COVID-19, Employment, Post-acute COVID-19 syndrome, SARS-CoV-2, Cross-sectional study, Health-related quality of life
Plan
| Funding: HN is supported by The University of British Columbia Clinician Investigator Program and a CAN-TAP-TALENT & Michael Smith Health Research BC Postdoctoral Fellowship. WZ has been supported by a Michael Smith Health Research BC Scholar award. This study was funded in part by the St. Paul's Foundation and British Columbia Ministry of Health. |
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| Conflict of Interest: HN is a member of the Canadian Guidelines for Post-COVID-19 Condition Guideline Team for Pharmacologic and Nonpharmacologic Clinical Interventions. |
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| Role of Funder: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. |
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