Precision medicine for asthma treatment: Unlocking the potential of the epigenome and microbiome - 13/07/24
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Abstract |
Asthma is a leading worldwide biomedical concern. Patients can experience life-threatening worsening episodes (exacerbations) usually controlled by anti-inflammatory and bronchodilator drugs. However, substantial heterogeneity in treatment response exists, and a subset of patients with unresolved asthma carry the major burden of this disease. The study of the epigenome and microbiome might bridge the gap between human genetics and environmental exposure to partially explain the heterogeneity in drug response. This review aims to provide a critical examination of the existing literature on the microbiome and epigenetic studies examining associations with asthma treatments and drug response, highlight convergent pathways, address current challenges, and offer future perspectives. Current epigenetic and microbiome studies have shown the bilateral relationship between asthma pharmacologic interventions and the human epigenome and microbiome. These studies, focusing on corticosteroids and to a lesser extent on bronchodilators, azithromycin, immunotherapy, and mepolizumab, have improved the understanding of the molecular basis of treatment response and identified promising biomarkers for drug response prediction. Immune and inflammatory pathways (eg, IL-2, TNF-α, NF-κB, and C/EBPs) underlie microbiome–epigenetic associations with asthma treatment, representing potential therapeutic pathways to be targeted. A comprehensive evaluation of these omics biomarkers could significantly contribute to precision medicine and new therapeutic target discovery.
Le texte complet de cet article est disponible en PDF.Key words : Bacteria, biomarker, DNA methylation, drug response, epigenetics, EWAS, microbiota, omics, personalized medicine, respiratory disease
Abbreviations used : BDR, C/EBP, CCL, DMR, DNAm, eQTM, EWAS, ICS, MAPK, mbGWAS, mbQTL, meQTL, miRNA, NF-κB, OCS, SCFA, SIT, T2
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The last 2 authors contributed equally to this article, and both should be considered senior author. |
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