Association of Growth During Infancy with Neurodevelopment and Obesity in Children Born Very Preterm: The Environmental Influences on Child Health Outcomes Cohort - 09/07/24
, Elizabeth T. Jensen, MPH, PhD 2, Joe X. Yi, MS 1, Barry Lester, PhD 3, Judy L. Aschner, MD 4, 5, Annemarie Stroustrup, MD, MPH 6, Xueying Zhang, PhD 7, Monica McGrath, ScD 8, Keia Sanderson, MD, MSCR 1, 9, Robert M. Joseph, PhD 10, Rachana Singh, MD, MS 11, Amanda L. Thompson, PhD 12, Julie Hofheimer, PhD 1, Betty Vohr, MD 13, Elisabeth McGowan, MD 13, Hudson Santos, PhD 14, Rebecca C. Fry, PhD 15on behalf
of program collaborators for Environmental influences on Child Health Outcomes∗
Abstract |
Objective |
To evaluate associations between change in weight z score after neonatal intensive care unit (NICU) discharge and neurodevelopmental outcomes and obesity at 12-48 months of age among individuals born very preterm.
Study design |
This secondary analysis used data from infants born very preterm participating in the Environmental influences on Child Health Outcomes cohort (n = 1400). Growth during infancy was calculated as change in weight z score between NICU discharge and follow-up at a mean of 27 months of age. Very low weight gain was defined as a change in weight z score <−1.67; very high weight gain was a change in weight z score >1.67. Neurodevelopmental outcomes included the Bayley Scales of Infant and Toddler Development, Child Behavior Checklist 1.5-5 years, and Modified Checklist for Autism in Toddlers. Multivariable linear regression was used to estimate associations between increase in weight z score and neurodevelopmental outcomes.
Results |
Very low weight gain between NICU discharge and follow-up (experienced by 6.4% of participants) was associated with lower scores on cognitive (adjusted mean difference: −4.26; 95% CI: −8.55, −0.04) and language (adjusted mean difference: −4.80; 95% CI: −9.70, −0.11) assessments. Very high weight gain (experienced by 13.6% of participants) was associated with an increased obesity risk (adjusted relative risk: 6.20; 95% CI: 3.99, 9.66) but not with neurodevelopmental outcomes.
Conclusions |
Very high weight gain in the first 12-48 months after NICU discharge was associated with a higher risk of obesity at follow-up; very low weight gain was associated with lower scores on cognitive and language assessments.
Le texte complet de cet article est disponible en PDF.Keywords : autistic disorder, behavior, developmental outcomes, extremely premature infant, very preterm birth, weight gain
Abbreviations : BMI, BSID, BSID-II, BSID-III, CBCL, DINE, ECHO, ELGAN, IHDP, IVH, M-CHAT, MDI, NICU, NOVI
Plan
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Vol 271
Article 114050- août 2024 Retour au numéro
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