Diagnostic performance of sixteen biomarkers for MASLD: A study in a Mexican cohort - 27/06/24
Highlights |
• | Evaluation of sixteen potential biomarkers for metabolic Dysfunction-associated steatotic liver disease (MASLD) diagnosis revealed significant differences between MASLD individuals and healthy controls. |
• | Sex-specific differences in sensitivity, specificity, and cut-off values underline the necessity of considering biological sex in MASLD research, advocating for sex-tailored diagnostic and treatment strategies. |
• | After adjusting for demographics, TyG-WC index was the best predictor for MASLD. |
Abstract |
Background and aims |
Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) poses a heightened cardiovascular risk. Identifying efficient biomarkers for early MASLD detection in resource-limited Latin American regions is crucial. We aimed to evaluate the diagnostic efficacy of sixteen biomarkers for MASLD in Mexican individuals.
Methods |
In this cross-sectional and analytical study, steatosis was assessed using vibration-controlled transient elastography. MASLD was defined according to international standards. Assessed biomarkers included: Visceral Fat (VF), Waist Circumference (WC), Waist-Height Ratio (WHtr), Waist-Hip Ratio (WHr), Visceral Adiposity Index (VAI), Hepatic Steatosis Index (HSI), Body Mass Index (BMI), Homeostatic Model Assessment (HOMA), Weight-Adjusted-Waist Index (WWI), Lipid Accumulation Product (LAP), Uric Acid-Creatinine Ratio (UACR), Triglyceride-Glucose Index (TyG) and its variants TyG-WC, TyG-HDL, TyG-BMI, TyG-WHtr.
Results |
161 participants were included, of which 122 met MASLD criteria (56 % women, age 53.9 years [47.5–64]) and 39 were healthy controls (76 % women, age 52 [45–64]). The AUROCs of the biomarkers for MASLD were: TyG-WC (0.84), LAP (0.84), TyG-BMI (0.82), TyG-WHtr (0.80), WC (0.78), TyG (0.77), WHtr (0.75), BMI (0.76), VF (0.75), HSI (0.75), TyG-HDL (0.75), WHr (0.72), VAI (0.73), UA/CR (0.70), HOMA (0.71), and WWI (0.69). Sex-based differences were observed. After adjusting for sociodemographic variables, the TyG-WC index was the best predictor of MASLD.
Conclusions |
In conclusion, our results underscore the potential of several noninvasive biomarkers for MASLD assessment in a Mexican population, highlighting variations in diagnostic efficacy and cut-off values between sexes. After adjusting, TyG-WC was the best MASLD predictor.
Le texte complet de cet article est disponible en PDF.Keywords : MASLD, Non-invasive biomarkers, Diagnostic performance, Liver diagnosis
Abbreviations : masld, nafld, t2dm, cap, bmi, vf, hb, ua, hdl, ldl, tg, ast, alt, ap, hsi, homa, lap, tyg, tyg-bmi, tyg-hdl-c
Plan
Vol 48 - N° 7
Article 102400- août 2024 Retour au numéro
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