Pathology of Squamous Cell Carcinoma of the Penis: Back to Square One - 24/06/24

Doi : 10.1016/j.ucl.2024.03.003

Diego F. Sanchez, MD, MSc ^a,^⁎ , Pedro Oliveira, MD ^b
^a Translational Oncogenomics Group, Manchester Cancer Research Centre & CRUK-MI, Wilmslow Road, Manchester M20 4GJ, UK
^b Department of Pathology, Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK

^∗Corresponding author.

Résumé

The landscape of squamous cell carcinoma of the penis (SCC-P) has undergone a significant transformation since the new World Health Organization classification of genitourinary cancers and recent European Association of Urology/American Association of Clinical Oncology guidelines. These changes emphasize the necessity to categorize SCC-P into 2 groups based on its association with human papillomavirus (HPV) infection. This shift has major implications, considering that prior knowledge was derived from a mix of both groups. Given the distinct prognosis, treatment options, and staging systems observed for HPV-associated tumors in other body areas, the question now arises: will similar patterns emerge for SCC-P?

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Keywords : Penile cancer etiology, Penile cancer pathology, Human papillomavirus, p16, Carcinogenesis, Penile intraepithelial neoplasia