Epidemiological surveillance of acute respiratory infections based on targeted metagenomic next generation sequencing during the flu season after COVID-19 pandemic in Beijing - 13/06/24

Doi : 10.1016/j.jinf.2024.106188

Bing Han ^a,^{^{1
These authors contributed equally.}}, Xu-ming Li ^b,^{^{1
These authors contributed equally.}}, Ran Li ^c,^{^{1
These authors contributed equally.}}, Wu Ning ^d,^{^{1
These authors contributed equally.}}, Yuan-yuan Zhang ^e,^f,^g,^h,^{^{1
These authors contributed equally.}}, Yan-fen Tang ^a,ⁱ, Ye Zhang ^b, Long Hu ^b, Jian-dong Li ^j, Gang Liu ^k, Dan Zhang ^d, Li Gu ^c, Han Xia ^b, Xi Wang ^e,^f,^g,^h,^⁎ , Rong-meng Jiang ^a,^⁎
^a Diagnosis and Treatment Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
^b Department of Scientific Affairs, Hugobiotech Co., Ltd., Bejing 100176, China
^c Department of Infectious and Clinical Microbiology, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100043, China
^d Department of Infectious Diseases, Peking University Shougang Hospital, Beijing 100144, China
^e National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing100015, China
^f Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
^g Beijing Institute of Infectious Diseases, Beijing 100015, China
^h National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
ⁱ Department of Respiratory, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
^j NHC Key Laboratory of Medical Virology and Viral Diseases, NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
^k Department of Infectious Diseases, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing 100045, China

^⁎Correspondence to: Diagnosis and Treatment Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing 100015, China.Diagnosis and Treatment Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical UniversityNo. 8 Jingshun East Street, Chaoyang DistrictBeijing100015China^⁎⁎Correspondence to: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical UniversityBeijing100015China

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Highlights

•	During flu season, large-scale multicenter ARI surveillance conducted with tNGS.
•	tNGS achieved 80.80% positivity, with bacteria at 53.76% and RNA viruses at 76.24%.
•	Positivity rates for IAV and IBV: 22.16% and 25.28%, showing distinct trends.
•	Exactly 34.4% samples show mixed infections, primarily bacterial and viral (25.84%).

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