The pattern of cortical thickness associated with executive dysfunction in MCI and SCC: The MEMENTO cohort - 12/06/24

Doi : 10.1016/j.neurol.2024.02.394

D. Andriuta ^a,⁎ , M. Roussel ^a, G. Chene ^b, C. Fischer ^c,^d, J.-F. Mangin ^c,^d, B. Dubois ^c,^e, B. Vellas ^f, F. Pasquier ^g, F. Tison ^h, F. Blanc ⁱ, O. Hanon ^j,^k, C. Paquet ^l, A. Gabelle ^m, M. Ceccaldi ⁿ, C. Annweiler ^o,^p,^q, P. Krolak-Salmon ^r, R. David ^s,^t, I. Rouch-Leroyer ^u, A. Benetos ^v, O. Moreaud ^w, F. Sellal ^x,^y, I. Jalenques ^z, P. Vandel ^aa, V. Bouteloup ^b, O. Godefroy ^a
the MEMENTO Study Group^¹
A full list of the MEMENTO Study GROUP collaborators is listed in the additional file.
^a Department of Neurology and Functional Neuroscience and Pathology Laboratory, Jules-Verne University of Picardy, Amiens University Hospital, CHU de Amiens-Picardie, 80054 Amiens, France
^b School of Public Health, Inserm U1219, institut de santé publique, d’épidémiologie et de développement, université de Bordeaux, CHU de Bordeaux, Bordeaux, France
^c University Hospital, Sorbonne Universities, Pierre-et-Marie-Curie University, 75006 Paris, France
^d Institut du cerveau et la moelle (ICM), hôpital Pitié-Salpêtrière, Paris, France
^e Department of Neurology, Institute of Memory and Alzheimer's Disease (IM2A), Brain and Spine Institute (ICM) UMR S 1127, AP–HP Pitié-Salpêtrière, Paris, France
^f Memory Resource and Research Centre of Toulouse, CHU de Toulouse, hôpital La Grave-Casselardit, Toulouse, France
^g Memory Resource and Research Centre of Lille, hôpital Roger-Salengro, CHRU de Lille, 59000 Lille, France
^h Institute for Neurodegenerative diseases, CMRR, University and University Hospital of Bordeaux, Bordeaux, France
ⁱ Department of Neurology, CHU de Strasbourg, Strasbourg, France
^j Memory Resource and Research Centre of Paris Broca, hôpital Broca, AP–HP, 75013 Paris, France
^k Université Paris Descartes, Sorbonne-Paris-Cité, EA 4468, Paris, France
^l Cognitive Neurology Centre, groupe hospitalier Saint-Louis-Lariboisière–Fernand-Widal, université de Paris, Paris, France
^m Memory Resource and Research Centre of Montpellier, Hôpital Gui-de-Chauliac, CHU de Montpellier, 34000 Montpellier, France
ⁿ Memory Resource and Research Centre of Marseille, hôpital La Timone, CHU de Marseille, 13000 Marseille, France
^o Department of Geriatric Medicine and Memory Clinic, Research Center on Autonomy and Longevity, University Hospital, Angers, France
^p UPRES EA 4638, University of Angers, Angers, France
^q Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
^r Memory Resource and Research Centre of Lyon, hospices civils de Lyon, hôpital des Charpennes, 69000 Lyon, France
^s Memory Resource and Research Centre of Nice, CHU de Nice, Nice, France
^t Institut Claude-Pompidou, EA 7276 CoBTeK “Cognition Behaviour Technology”, 06100 Nice, France
^u Memory Resource and Research Centre of Saint-Étienne, hôpital Nord, CHU de Saint-Étienne, 42000 Saint-Étienne, France
^v Memory Resource and Research Centre of Nancy, CHU de Nancy, 54000 Nancy, France
^w Memory Resource and Research Centre of Grenoble, hôpital de la Tronche, CHU de Grenoble Alpes, 38000 Grenoble, France
^x Memory Resource and Research Centre of Strasbourg/Colmar, hôpitaux civils de Colmar, 68000 Colmar, France
^y Inserm U-1118, Strasbourg University, 67000 Strasbourg, France
^z Memory Resource and Research Centre of Clermont-Ferrand, Clermont-Auvergne University, CHU de Clermont-Ferrand, 63000 Clermont-Ferrand, France
^aa Memory Resource and Research Centre of Besançon, hôpital Jean-Minjoz, hôpital Saint-Jacques, CHU de Besançon, 25000 Besançon, France

^*Corresponding author. Department of Neurology, Amiens University Hospital, 80054 Amiens, France.Department of Neurology, University HospitalAmiens80054France

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Abstract

Background

The association between the pattern of cortical thickness (CT) and executive dysfunction (ED) in mild cognitive impairment (MCI) and subjective cognitive complaints (SCC) is still poorly understood. We aimed to investigate the association between CT and ED in a large French cohort (MEMENTO) of 2323 participants with MCI or SCC.

Methods

All participants with available CT and executive function data (verbal fluency and Trail Making Test [TMT]) were selected (n=1924). Linear regressions were performed to determine relationships between executive performance and the brain parenchymal fraction (BPF) and CT using FreeSurfer.

Results

The global executive function score was related to the BPF (sß: 0.091, P<0.001) and CT in the right supramarginal (sß: 0.060, P=0.041) and right isthmus cingulate (sß: 0.062, P=0.011) regions. Literal verbal fluency was related to the BPF (sß: 0.125, P<0.001) and CT in the left parsorbitalis region (sß: 0.045, P=0.045). Semantic verbal fluency was related to the BPF (sß: 0.101, P<0.001) and CT in the right supramarginal region (sß: 0.061, P=0.042). The time difference between the TMT parts B and A was related to the BPF (sß: 0.048, P=0.045) and CT in the right precuneus (sß: 0.073, P=0.019) and right isthmus cingulate region (sß: 0.054, P=0.032).

Conclusions

In a large clinically based cohort of participants presenting with either MCI or SCC (a potential early stage of Alzheimer's disease [AD]), ED was related to the BPF and CT in the left pars orbitalis, right precuneus, right supramarginal, and right isthmus cingulate regions. This pattern of lesions adds knowledge to the conventional anatomy of ED and could contribute to the early diagnosis of AD.

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Keywords : Executive dysfunction, Alzheimer's disease, Mild cognitive impairment, Subjective cognitive complaints, Cortical thickness