Ultra-Wide-Field Optical Coherence Tomography and Gaussian Curvature to Assess Macular and Paravascular Retinoschisis in High Myopia - 07/06/24
Highlights |
• | The largest Gaussian curvature was predominantly found in the posterior pole. |
• | Inner RS presented as feather- or streak-like hyporeflective areas in enface images. |
• | Age and paravascular retinoschisis (PVRS) were significant risk factors for macular retinoschisis (MRS) occurrence. |
• | MRS and higher K1 were significantly associated with the presence of PVRS. |
• | The axial length (AL) and K1 values were associated with the severity of whole-image retinoschisis. |
Résumé |
Purpose |
To evaluate the severity and related factors of macular retinoschisis (MRS) and paravascular retinoschisis (PVRS) in high myopia (HM) using ultra-wide-field optical coherence tomography (UWF-OCT) and a novel Gaussian curvature (K).
Design |
A cross-sectional study.
Methods |
Patients diagnosed with HM in Peking Union Medical College Hospital were recruited between January 2022 and November 2022. The presence and severity of retinoschisis, along with the three highest K values, were assessed using UWF-OCT and en face images. Logistic regressions were employed to identify factors associated with MRS, PVRS, and the severity of retinoschisis in the 24 × 20 mm scan region.
Results |
A total of 108 HM eyes from 55 patients were recruited. The highest Gaussian curvature (K1) was predominantly found in the vascular arcade (43, 40%). Multivariable logistic regression found that age and PVRS were significant risk factors for MRS occurrence (P < .05), while MRS and higher K1 were significantly associated with the presence of PVRS in HM patients (P < .05). The axial length (AL) and spherical equivalent were associated with the severity of MRS, while AL and K1 values were associated with the severity of retinoschisis in the 24 × 20 mm scan region (P < .05).
Conclusions |
An association existed between large Gaussian curvature and the presence of MRS and PVRS, as well as the severity of retinoschisis in a wide field of view. UWF-OCT, which enables visualization of the central and peripheral retinal areas, holds promise as an imaging technique for the early detection of extrafoveal retinoschisis.
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| Supplemental Material available at AJO.com. |
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| Dr. Qing Zhao and Xinyu Zhao contributed equally as co-first authors. |
Vol 263
P. 70-80 - juillet 2024 Retour au numéro
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