Reactivation After Teprotumumab Treatment for Active Thyroid Eye Disease - 07/06/24
Résumé |
PURPOSE |
To determine the recurrence and reactivation rates after teprotumumab therapy for active thyroid eye disease.
DESIGN |
Retrospective consecutive case series.
METHODS |
This was a study of all patients followed for active thyroid eye disease at the Cole Eye Institute, Cleveland Clinic, treated with teprotumumab between May 2020 and May 2021. Patients with less than 6 months follow-up after completion of infusions were excluded. The primary outcome measure was reactivation, defined as a regression in proptosis (increase of ≥2 mm in either eye and to within ≤2 mm of pre-treatment level and Clinical Activity Score [CAS] worsening of 2 points or greater). Secondary outcome was diplopia response.
RESULTS |
A total of 21 patients were included in the study. The average long-term improvement in proptosis in the eye with more proptosis after teprotumumab was 1.57mm (range, –3 to 4 mm). Of the 17 initial responders, there were 8 reactivations (47%) and 2 isolated proptosis regressions (12%); Overall, 7 of 21 patients (33%) responded throughout the study period. Average time to regression was 12.25 months (range, 2-22.5 months). There was no statistically significant change in diplopia at final visit in any subgroup (P = 0.68 to >.99).
CONCLUSIONS |
At most, 33% of patients demonstrate continued response 2 years after teprotumumab treatment. The proptosis and CAS regression occurs in the setting of disease reactivation in 80% of regressions. Teprotumumab treatment appears to offer minimal long-term improvement in diplopia.
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Supplemental Material available at AJO.com. |
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Parts of the data in the manuscript were presented at the annual meeting of the International Orbit Society, 2023. |
Vol 263
P. 152-159 - juillet 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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