Clinical and molecular correlates of the Index of Severity for Eosinophilic Esophagitis - 06/06/24
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Graphical abstract |
Abstract |
Background |
The Index of Severity for Eosinophilic Esophagitis (I-SEE) is a new expert-defined clinical tool that classifies disease severity of eosinophilic esophagitis (EoE).
Objective |
We aimed to determine whether I-SEE is associated with patient characteristics, molecular features of EoE, or both.
Methods |
We analyzed a prospective cohort of patients with EoE from the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Associations between I-SEE and clinical and molecular features (assessed by an EoE diagnostic panel [EDP]) were assessed.
Results |
In 318 patients with chronic EoE (209 adults, 109 children), median total I-SEE score was 7.0, with a higher symptoms and complications score in children than adults (4.0 vs 1.0; P < .001) and higher inflammatory and fibrostenotic features scores in adults than children (3.0 vs 1.0 and 3.0 vs 0, respectively; both P < .001). Total I-SEE score had a bimodal distribution with the inactive to moderate categories and severe category. EDP score correlated with total I-SEE score (r = −0.352, P < .001) and both inflammatory and fibrostenotic features scores (r = −0.665, P < .001; r = −0.446, P < .001, respectively), but not with symptoms and complications scores (r = 0.047, P = .408). Molecular severity increased from inactive to mild and moderate, but not severe, categories. Longitudinal changes of modified I-SEE scores and inflammatory and fibrostenotic features scores reflected histologic and molecular activity.
Conclusions |
I-SEE score is associated with select clinical features across severity categories and with EoE molecular features for nonsevere categories, warranting further validation.
Le texte complet de cet article est disponible en PDF.Key words : Eosinophilic esophagitis, diagnostic panel, eosinophil, complications, outcome
Abbreviations used : CEGIR, EDP, EGID, EoE, eos/hpf, FDR, IQR, I-SEE, m-I-SEE, OMEGA
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