Prevention and management of VZV infection during pregnancy and the perinatal period - 01/06/24
Doi : 10.1016/j.idnow.2024.104857
Caroline Charlier a, b, ⁎ 
, Olivia Anselem c, Marion Caseris d, Marie Lachâtre e, Asmaa Tazi f, Marine Driessen g, Didier Pinquier h, Chemsa Le Cœur i, Aurélie Saunier j, Mathilde Bergamelli k, Roxane Gibert Vanspranghels l, Anaïs Chosidow m, Charles Cazanave n, Sophie Alain o, Karine Faure p, André Birgy q, François Dubos r, Philippe Lesprit s, Julie Guinaud t, Robert Cohen u, Jean-Winoc Decousser v, Emmanuel Grimprel w, Cyril Huissoud x, Julie Blanc y, Gilles Kayem z, Fanny Vuotto p, Christelle Vauloup-Fellous aa, ab
, Olivia Anselem c, Marion Caseris d, Marie Lachâtre e, Asmaa Tazi f, Marine Driessen g, Didier Pinquier h, Chemsa Le Cœur i, Aurélie Saunier j, Mathilde Bergamelli k, Roxane Gibert Vanspranghels l, Anaïs Chosidow m, Charles Cazanave n, Sophie Alain o, Karine Faure p, André Birgy q, François Dubos r, Philippe Lesprit s, Julie Guinaud t, Robert Cohen u, Jean-Winoc Decousser v, Emmanuel Grimprel w, Cyril Huissoud x, Julie Blanc y, Gilles Kayem z, Fanny Vuotto p, Christelle Vauloup-Fellous aa, ab a Université Paris Cité, Paris Centre University Hospital, Infectious Diseases Transversal Team, Infectious Diseases Department, AP-HP, FHU Prema, Paris, France
b Institut Pasteur, French National Reference Center and WHO Collaborating Center Listeria, Biology of Infection Unit, Inserm U1117, Paris, France
c Paris Centre University Hospital, Maternité Port-Royal AP–HP, FHU Prema, Paris, France
d Robert Debré University Hospital, Department of General Pediatrics, Pediatric Internal Medicine, Rheumatology and Infectious Diseases, AP-HP, Paris, France
e Paris Centre University Hospital, Clinical Vaccinology Center, AP-HP, Paris, France
f Université Paris Cité, Paris Centre University Hospital, Bacteriology Unit, French National Reference Center Streptococci, AP-HP, Institut Cochin, Inserm U1016, CNRS UMR8104, Paris, France
g Necker Enfants University Hospital, Department of Obstetrics and Fetal Medicine, AP-HP, Paris, France
h CHU Rouen, Department of Neonatal and Pediatric Intensive Care Medicine, Normandie University, UNIROUEN, INSERM U1245, Rouen, France
i Tours University Hospital, Infectious Diseases and Tropical Medicine Unit, Tours, France
j Périgueux Hospital, Infectious Diseases Unit, Périgueux, France
k Department of Clinical Sciences, Intervention and Technology (CLINTEC) Karolinska Institute, Division of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden
l Lille University Hospital, Department of Obstetrics, Lille, France
m CHI Villeneuve Saint Georges, Department of Pediatrics, Villeneuve Saint Georges, France
n CHU Bordeaux, Infectious and Tropical Diseases Department, Univ. Bordeaux, UMR 5234 CNRS, ARMYNE, Bordeaux, France
o Microbiology Department, and Medical Genomic Unit CHU Limoges, UMR Inserm 1092, RESINFIT, Limoges University, IFR GEIST, Medical Faculty, National Reference Center for Herpesviruses, Centre de Biologie et de Recherche en Santé (CBRS) Limoges, France
p CHU Lille, Infectious Diseases Unit, Lille, France
q Université Paris Cité, Robert Debré University Hospital, Microbiology Unit, AP-HP, IAME, UMR1137, INSERM, Paris, France
r Université Lille, CHU Lille, Pediatric Emergency Unit & Infectious Diseases, ULR2694: METRICS, F-59000 Lille, France
s CHR Grenoble-Alpes, Infectious Diseases Unit, Grenoble, France
t CHU La Réunion site sud, Neonatology and Neonatal Intensive Care Unit, Saint Pierre, France
u Université Paris Est, IMRB-GRC GEMINI, Unité Court Séjour, Petits Nourrissons, Service de Néonatologie, CHI Créteil, Créteil, France
v Université Paris Est Créteil, Henri Mondor University Hospital EOH, AP-HP, Créteil, France
w Service de pédiatrie générale et aval des urgences, hôpital Trousseau, Paris, APHP, Sorbonne Sorbonne Université Médecine, France
x Hospices Civils de Lyon, Service de gynécologie obstétrique de l HFME, 59 Bd Pinel, 69500 Bron, Université Claude Bernard, Lyon 1, INSERM U1208, Stem-Cell and Brain Research Institute, France
y Université de Marseille, Hôpital Nord University Hospital, Obstetrics Ward, Assistance Publique hôpitaux Marseille, Marseille, France
z Trousseau University Hospital, Obstetrics Ward, Assistance Publique – hôpitaux Paris, Sorbonne Université, FHU Prema, Paris, France
aa Division of Virology, WHO Rubella National Reference Laboratory, Groupe de Recherche sur les Infections pendant la grossesse (GRIG), Dept of Biology Genetics and PUI, Paris Saclay University Hospital, APHP, Paris, France
ab Université Paris-Saclay, INSERM U1184, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses, France
⁎Corresponding author at: Équipe Mobile Infectiologie, Groupe hospitalier Paris Centre Cochin Port-Royal, France.Équipe Mobile InfectiologieGroupe hospitalier Paris Centre Cochin Port-RoyalFrance
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Graphical abstract |
Highlights |
• | A chickenpox is more severe in pregnant women than in adults; it exposes the unborn child to three risks: congenital varicella syndrome, potentially severe varicella, and herpes zoster. |
• | In the event of VZV exposure in a non-immunized pregnant woman, prophylaxis consists in anti-VZV immunoglobulins during the ten days following contact (0.5 to 1 ml /kg, IVL). |
• | Maternal chickenpox during the seven days before / after birth can lead to severe neonatal chickenpox; this justifies administration of anti-VZV immunoglobulins to the newborn as soon as possible following birth (10 days maximum). |
• | This timeframe should be extended to 21 days before delivery for infants born before 28 weeks of amenorrhea or weighing less than 1000 g at birth. |
Keywords : Chickenpox, Zoster, Pregnancy, Neonate, Vaccination
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© 2024
The Author(s). Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 54 - N° 4
Article 104857- juin 2024 Retour au numéro
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