Is there an interest in systematic serum screening for aspergillosis in COVID-19 patients in a medical ward? - 01/06/24
, Louis Boehn a, Marcela Sabou b, Antoine Studer c, Axel Ursenbach a, d, Yves Hansmann a, Raoul Herbrecht e, Nicolas Lefebvre a, Valérie Letscher-Bru b, François Danion a, f
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Highlights |
• | Our study explores the interest of systematic screening of fungal markers for COVID-19- associated pulmonary aspergillosis in a medical ward. |
• | Our study does not support systematic screening of fungal markers in COVID-19 patients hospitalized outside an ICU. |
• | This approach should be explored in specific subgroups, such as immunocompromised COVID-19 patients. |
Abstract |
Purpose |
We evaluated the interest of systematic screening of serum fungal markers in patients hospitalized in a medical ward.
Methods |
We retrospectively analyzed all patients hospitalized in our infectious disease department from October 1st to October 31st, 2020 for COVID-19 without prior ICU admission, and for whom systematic screening of serum fungal markers was performed.
Results |
Thirty patients were included. The majority of patients received corticosteroids (96.7%). The galactomannan antigen assay was positive for 1/30 patients at D0, and 0/24, 0/16, 0/13 and 0/2 at D4, D7, D10 and D14 respectively. 1,3-ß-D-glucan was positive for 0/30, 1/24, 1/12, 0/12, 0/2 at D0, D4, D7, D10 and D14 respectively. No Aspergillus fumigatus PCR was positive. No cases of aspergillosis were retained.
Conclusion |
Our study does not support the interest of systematic screening of fungal markers in immunocompetent patients with COVID-19 in a conventional unit.
Le texte complet de cet article est disponible en PDF.Keywords : COVID-19, Aspergillosis, COVID-19-associated pulmonary aspergillosis, Fungal screening
Plan
Vol 54 - N° 4
Article 104918- juin 2024 Retour au numéro
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