FEV1 and FVC as robust risk factors for cardiovascular disease and mortality: Insights from a large population study - 20/05/24
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Abstract |
Introduction |
Data is limited on influence of forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in a large adult population, including individuals with normal spirometry at baseline.
Methods |
Using the UK Biobank cohort, a multivariable Cox regression analysis was conducted on 406,424 individuals to examine the association between FEV1 and FVC, categorized into three groups based on their percentage of predicted values (%pred) (≥80, 60–80 and < 60), and overall mortality, cardiovascular mortality, myocardial infarction, stroke, and heart failure over approximately 12.5 years. Moreover, a subgroup analysis was conducted on 295,459 individuals who had normal spirometry.
Results |
Reduced FEV1 and FVC %pred values were associated with an elevated risk across all studied outcomes. Individuals with the lowest FEV1 and FVC %pred values (<60 %) exhibited HR of 1.83 (95 % CI 1.74–1.93) and 1.98 (95 % CI 1.76–2.22) for overall mortality, and 1.96 (95 % CI 1.83–2.1) and 2.26 (95 % CI 1.94–2.63) for cardiovascular mortality. Moreover, a graded association was observed between lower FEV1 and FVC %pred, even among never smokers and individuals with normal spirometry at baseline.
Discussion |
Reduced FEV1 and FVC represent robust risk factors for cardiovascular disease and mortality. The fact that the increased risk was evident also at FEV1 and FVC levels exceeding 80 %pred challenges the contemporary classification of lung function categories and the notion that the entire FEV1- and FVC-range above 80 % of predicted represents a normal lung function.
Le texte complet de cet article est disponible en PDF.Keywords : FEV1, FVC, Cardiovascular disease, Mortality, Population attributable fraction
Abbreviations : BMI, chronic kidney disease. CVD, estimated glomerulation filtration rate. FEV1: forced expiratory volume. FVC, International Statistical Classification of Diseases. LDL, population attributable fraction. PRISm
Plan
Vol 227
Article 107614- juin 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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