Temporal variations in the serogroup distribution of invasive meningococcal disease in Quebec, Canada, due to emerging unique clade of serogroup Y strain belonging to the Sequence Type-23 clonal complex - 17/05/24
, Genevieve Deceuninck b, c, Courtney Meilleur a, Jianwei Zhou a, Brigitte Lefebvre d, Philippe De Wals eSummary |
Objective |
To identify recent trends in invasive meningococcal diseases (IMD) in Quebec, Canada, with a focus on MenY cases and MenY strains.
Methods |
IMD cases and MenY strains from January 1, 2015 to August 11, 2023 were analyzed for clonal analysis and prediction of susceptibility to MenB vaccines. MenY strains of ST-23 CC from Quebec were analyzed with global MenY strains by core-genomic multi-locus sequence typing (cg-MLST).
Results |
Since 2015 the serogroup distribution of IMD in Quebec has shifted from predominantly MenB to mainly MenY, with most (80.9 %) of the latter belonging to ST-23 CC. The median age of MenY cases due to ST-23 CC were statistically younger than MenY cases due to non-ST-23 CC. MenY of ST-23 CC showed genetic diversity and the major genetic cluster were similar to the Swedish Y1 strain. The increase in invasive MenY disease in Quebec was due to a sub-clade of Lineage 23.1 which caused an elevated proportion of severe disease in young adults.
Conclusion |
The increase in invasive MenY disease in Quebec, Canada was driven by the expansion of a sub-clade of Lineage 23.1 in young adults. Currently available quadrivalent A,C,W,Y-conjugate meningococcal vaccines were predicted to provide protection against these strains.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Since 2015 IMD cases in Quebec has shifted from largely MenB to predominantly MenY. |
• | Increase in MenY was due to the ST-23 clonal complex causing IMD in young people. |
• | cg-MLST of Quebec ST-23 CC MenY revealed three distinct clades. |
• | Quebec ST-23 CC MenY were related to international MenY Lineages. |
• | A sub-clade of Lineage 23.1 caused MenY disease in young adults with severe disease. |
Keywords : Invasive meningococcal disease, ST-23 CC, Core-genome multi-locus sequence typing, Vaccine protection
Plan
Vol 88 - N° 6
Article 106163- juin 2024 Retour au numéro
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