The potential value of a quantitative PCR assay for assessing respiratory samples in approaching a laboratory diagnosis of pulmonary mucormycosis - 17/05/24
Doi : 10.1016/j.jinf.2024.106160
Ya-Ping Chen a, Cong-Tat Cia b, Ya-Ting Hsu a, Po-Lin Chen c, Tsai-Yun Chen a, Jen-Chieh Lee b, Sin-Syue Li a, Ming-I Hsieh d, Hsuan-Chen Wang d, Chi-Jung Wu c, d, ⁎ 
a Division of Hematology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
b Division of Critical Care Medicine, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
c Division of Infectious Diseases, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
d National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan
⁎Correspondence to: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 5F, No.367, Sheng-Li Road, North District, Tainan 70456, Taiwan.National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes5F, No.367, Sheng-Li Road, North DistrictTainan70456Taiwan
Highlights |
• | Mucorales qPCR aids in the aetiological diagnosis of breakthrough invasive fungal infections not responding to Aspergillus-targeted therapy. |
• | Narrow hyphal widths (3−7 µm) were observed on histology of mucormycosis caused by Cunninghamella bertholletiae, which could be differentiated from aspergillosis by Mucorales qPCR using fresh lung tissue. |
• | Further refinement of Mucorales qPCR assays for specific detection of C. bertholletiae aids in pathogen-tailored management. |
Plan
© 2024
The Author(s). Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 88 - N° 6
Article 106160- juin 2024 Retour au numéro
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