Allergic rhinitis phenotypes with distinct transcriptome profiles in children: A birth cohort - 03/05/24
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Graphical abstract |
Abstract |
Background |
Allergic rhinitis (AR) phenotypes in childhood are unclear.
Objectives |
This study sought to determine AR phenotypes and investigate their natural course and clinical and transcriptomic characteristics.
Methods |
Latent class trajectory analysis was used for phenotyping AR in 1050 children from birth through 12 years using a birth cohort study. Blood transcriptome analyses were performed to define the underlying mechanisms of each phenotype.
Results |
Five AR phenotypes were identified: early onset (n = 88, 8.4%), intermediate transient (n = 110, 10.5%), late onset (n = 209, 19.9%), very late onset (n=187, 17.8%), and never/infrequent (n = 456, 43.4%). Children with early-onset AR were associated with higher AR severity and sensitizations to foods at age 1 year and inhalants at age 3 years and asthma symptoms, but not with bronchial hyperresponsiveness (BHR). Children with late-onset AR phenotype associated with sensitizations to various foods at age 1 year but not from age 3 years, and to inhalants from age 7 years and with asthma with BHR. Children with very late–onset AR phenotype associated with sensitizations to foods throughout preschool age and to inhalants at ages 7 and 9 years and with asthma with BHR. Transcriptome analysis showed that early-onset AR was associated with viral/bacterial infection–related defense response, whereas late-onset AR was associated with T cell–related immune response.
Conclusions |
Early-onset AR phenotype was associated with sensitization to foods and inhalants at an early age and asthma symptoms, but not with BHR, whereas very late– and late-onset AR phenotypes were positively associated with sensitization to inhalants and asthma with BHR. Transcriptomic analyses indicated that early- and late-onset AR phenotypes had distinct underlying mechanisms related to AR as well.
Le texte complet de cet article est disponible en PDF.Key words : Allergic rhinitis, phenotype, comorbidity, trajectory, transcriptome, children
Abbreviations used : AD, AR, BHR, DEG, FA, Feno, LCTA, OAS
Plan
Vol 153 - N° 5
P. 1319-1329 - mai 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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