Change in Age profile of Respiratory Syncytial Virus disease over the course of annual epidemics: a multi-national study - 30/04/24
VRS Study Group in Lyonb
Rolf Kramer j, Lisa Staadegaard a, Susanne Heemskerk a, Jojanneke van Summeren a, Adam Meijer i, John Paget aSummary |
Objectives |
We aimed to study whether the percentwise age distribution of RSV cases changes over time during annual epidemics.
Methods |
We used surveillance data (2008–2019) from the Netherlands, Lyon (France), Portugal, Singapore, Ecuador, South Africa, and New Zealand. In each country, every season was divided into “epidemic quarters”, i.e. periods corresponding to each quartile of RSV cases. Multinomial logistic regression models were fitted to evaluate whether the likelihood of RSV cases being aged <1 or ≥5 years (vs. 1 to <5) changed over time within a season.
Results |
In all countries, RSV cases were significantly more likely to be aged <1 year in the 4th vs. 1st epidemic quarter; the relative risk ratio [RRR] ranged between 1.35 and 2.56. Likewise, RSV cases were significantly more likely to be aged ≥5 years in the 4th vs. 1st epidemic quarter (except in Singapore); the RRR ranged from 1.75 to 6.70. The results did not change when stratifying by level of care or moving the lower cut-off to 6 months.
Conclusions |
The age profile of RSV cases shifts within a season, with infants and adolescents, adults, and the elderly constituting a higher proportion of cases in the later phases of annual epidemics. These findings may have implications for RSV prevention policies with newly approved vaccines.
Le texte complet de cet article est disponible en PDF.Highlights |
• | We studied whether the age of RSV cases changes over time during annual epidemics. |
• | We used surveillance data (2008–2019) from seven countries around the world. |
• | RSV cases become more likely to be aged <1 or >5 years as the epidemics unfolds. |
• | The trend is largely consistent across countries and robust to sensitivity analyses. |
Keywords : RSV, Age, Surveillance
Plan
Vol 88 - N° 5
Article 106154- mai 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?