Novel antivirals for severe enterovirus infection in immunocompromised hosts; A case series - 30/04/24
Doi : 10.1016/j.jinf.2024.106142
Andrea Meinhardt ⁎, 1 
Department of Immunology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
Department of Paediatric Haematology, Oncology and Immunodeficiencies, Justus, Liebig-University, Giessen, Germany
⁎Correspondence to: University Children’s Hospital, Paediatric Haematology, Oncology and Immunodeficiencies, Feulgenstraße 12, 35385 Giessen, Germany.University Children’s Hospital, Paediatric Haematology, Oncology and ImmunodeficienciesFeulgenstraße 12Giessen35385Germany
Liam Reilly 1
Department of Immunology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
Department of Paediatric Infectious Diseases and Immunology, Royal Hospital for Children, Glasgow, UK
Marios Kaliakatsos
Department of Neurology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
Khaled Abdel-Aziz
Department of Neurology, St George's University Hospital NHS Foundation Trust, London, UK
Sondus Alsharidah
Paediatric Immunology, Leeds Children`s Hospital, Leeds, UK
Paediatric Haematology-Oncology Stem Cell Transplant Department at NBK Children's Hospital, Kuwait
Claire Booth, Kritika Chetty
Department of Immunology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, UK
Jennifer Evans
Paediatric Infectious Disease and Immunology, University Hospital of Wales, Cardiff, UK
Laura Ferreras-Antolín
Paediatric Infectious Disease and Immunology, St George’s University Hospitals, NHS Foundation Trust, London, UK
Clare M. Galtrey
Department of Neurology, St George's University Hospital NHS Foundation Trust, London, UK
Suba Guruprasad
Paediatric Infectious Disease and Immunology, St George’s University Hospitals, NHS Foundation Trust, London, UK
Jane Hassell
Department of Neurology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
Heikki Hyöty
Faculty of Medicine and Health Technology, Tampere University, Finland
Fimlab Laboratories, Tampere, Finland
Alexandra Y. Kreins
Department of Immunology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, UK
Michael P. Lunn
Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK
Kshitij Mankad
Department of Radiology, Great Ormond Street Hospital NHS Foundation Trust, London, UK
Siske Struik
Paediatric Infectious Disease and Immunology, University Hospital of Wales, Cardiff, UK
Elizabeth Whittaker
Department of Paediatric Infectious Diseases, St Mary's Hospital, Imperial College NHS Healthcare Trust, London, UK
Department of Academic Paediatrics, Imperial College, 2nd Floor Wright-Fleming Building, London, UK
Austen Worth
Department of Immunology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
Patrick Yong, Liqun Zhang
Department of Neurology, St George's University Hospital NHS Foundation Trust, London, UK
Judith Breuer 2
Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, UK
Department of Infectious Diseases, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
Seilesh Kadambari 2
Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, UK
Department of Infectious Diseases, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
Highlights |
• | Enteroviruses can cause significant morbidity and mortality in immunocompromised. |
• | Serial tests in multiple compartments may be necessary to identify Enterovirus. |
• | Metagenomics on brain biopsy may be justified when conventional testing is negative. |
• | Early combination antiviral treatments can improve outcomes in immunocompromised. |
• | Antiviral therapy acts as bridging therapy until immune reconstitution. |
Plan
© 2024
The Author(s). Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 88 - N° 5
Article 106142- mai 2024 Retour au numéro
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